Fluorescent and colorimetric probes for detection of thiols

Xiaoqiang Chen, Ying Zhou, Xiaojun Peng, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

1451 Scopus citations


Due to the biological importances of thiols, such as cysteine, homocysteine and glutathione, the development of optical probes for thiols has been an active research area in recent few years. This critical review focuses on the fluorescent or colorimetric sensors for thiols according to their unique mechanisms between sensors and thiols, including Michael addition, cyclization with aldehyde, cleavage of sulfonamide and sulfonate ester by thiols, cleavage of selenium-nitrogen bond by thiols, cleavage of disulfide by thiols, metal complexes-oxidation-reduction, metal complexes-displace coordination, nano-particles and others (110 references.

Original languageEnglish
Pages (from-to)2120-2135
Number of pages16
JournalChemical Society Reviews
Issue number6
StatePublished - 25 May 2010


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