FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals

Hyo Jung Kang, Sujung Yoon, Suji Lee, Koeul Choi, Sihwan Seol, Shinwon Park, Eun Namgung, Tammy D. Kim, Yong An Chung, Jungyoon Kim, Jung Soo Han, In Kyoon Lyoo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTSD. Using a translational approach, candidate miRNAs found to alter in expression within the medial prefrontal cortex of FKBP5 knockout mice were selected. Each candidate miRNA was examined in the serum of 48 recently traumatized individuals with PTSD and 47 healthy individuals. Multimodal imaging was also conducted to identify the neural correlates for the expression of candidate exosomal miRNAs in response to trauma exposure. Differential miRNA expression was found according to PTSD diagnosis in two composite marker groups. The differential miRNA expression between the composite marker groups contributed to PTSD symptom severity, which may be explained by differential recruitment of prefrontolimbic activity in brain imaging. The present study reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic markers of PTSD. The corroborative evidence from multiple levels including molecular, brain, and behavioral indicates that these epigenetic biomarkers may serve as complementary measures for the diagnosis and prognosis prediction of PTSD in recently traumatized individuals.

Original languageEnglish
Pages (from-to)3353
Number of pages1
JournalScientific Reports
Issue number1
StatePublished - 25 Feb 2020


Dive into the research topics of 'FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals'. Together they form a unique fingerprint.

Cite this