@article{58d50235ff8741439c94a8664811d551,
title = "Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent",
abstract = "(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50 = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice. ",
author = "Hwang, {Soo Yeon} and Park, {Soo Yeon} and Hong, {Jung Yeon} and Lee, {Soo Yeon} and Shin, {Jae Ho} and Younghwa Na and Sohn, {Myung Hyun} and Yoon, {Ho Geun} and Youngjoo Kwon",
note = "Funding Information: This work was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0104), and the National Research Foundation of Korea (NRF) grant funded by the Korea government (2018R1A5A2025286 and 2018R1A5A2025079). Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",
year = "2020",
month = sep,
day = "4",
doi = "10.1039/d0cc03553j",
language = "English",
volume = "56",
pages = "9795--9798",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "68",
}