Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice

Michung Yoon, Sunhyo Jeong, Hyunghee Lee, Miyoung Han, Joo Hyoung Kang, Eun Young Kim, Mina Kim, Goo Taeg Oh

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

We investigated whether fenofibrate improves lipid metabolism and obesity in female ovariectomized (OVX) or sham-operated (SO) low density lipoprotein receptor-null (LDLR-null) mice. All mice fed a high-fat diet exhibited increases in serum triglycerides and cholesterol as well as in body weight and white adipose tissue (WAT) mass compared to mice fed a low fat control diet. However, fenofibrate prevented high-fat diet-induced increases in body weight and WAT mass in female OVX LDLR-null mice, but not in SO mice. In addition, administration of fenofibrate reduced serum lipids and hepatic apolipoprotein C-III mRNA while increasing the mRNA of acyl-CoA oxidase in both groups of mice, however, these effects were more pronounced in OVX LDLR-null mice. The results of this study provide first evidence that fenofibrate improves both lipid metabolism and obesity, in part through PPARα activation, in female OVX LDLR-null mice.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume302
Issue number1
DOIs
StatePublished - 28 Feb 2003

Keywords

  • Adipose tissue
  • Body weight
  • Fenofibrate
  • LDLR-null
  • Lipid
  • PPARα

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