Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring

Sangmi Lee, Kyung A. Lee, Gyu Yeon Choi, Mina Desai, Sun Hwa Lee, Myung Geol Pang, Inho Jo, Young Ju Kim

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objective: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. Study design: From 10d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. Results: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p<0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p<0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. Conclusion: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.

Original languageEnglish
Pages (from-to)908-914
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume26
Issue number9
DOIs
StatePublished - Jun 2013

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2011-0004200, 2010-0026225) and Global Top 5 Project (2012).

Keywords

  • Adiponectin
  • Fetal programming
  • Food restriction
  • Leptin
  • Obesity

Fingerprint

Dive into the research topics of 'Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring'. Together they form a unique fingerprint.

Cite this