Abstract
Objective: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. Study design: From 10d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. Results: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p<0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p<0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. Conclusion: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
Original language | English |
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Pages (from-to) | 908-914 |
Number of pages | 7 |
Journal | Journal of Maternal-Fetal and Neonatal Medicine |
Volume | 26 |
Issue number | 9 |
DOIs | |
State | Published - Jun 2013 |
Bibliographical note
Funding Information:This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2011-0004200, 2010-0026225) and Global Top 5 Project (2012).
Keywords
- Adiponectin
- Fetal programming
- Food restriction
- Leptin
- Obesity