Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer

Eun Mi Song, Jeong Sik Byeon, Sun Mi Lee, Hyun Ju Yoo, Su Jung Kim, Sun Ho Lee, Kiju Chang, Sung Wook Hwang, Dong Hoon Yang, Jin Yong Jeong

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated. Aims: We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls. Methods: We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography–mass spectrometry. Results: Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces, P = 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces, P = 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces, P = 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces, P = 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls. Conclusions: There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC.

Original languageEnglish
Pages (from-to)1229-1236
Number of pages8
JournalDigestive Diseases and Sciences
Volume63
Issue number5
DOIs
StatePublished - 1 May 2018

Keywords

  • Colorectal neoplasm
  • Fatty acids
  • Feces
  • Metabolome

Fingerprint

Dive into the research topics of 'Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer'. Together they form a unique fingerprint.

Cite this