Abstract
Introduction: Global and regional sympathetic activity in the heart can be evaluated using [123I]meta-iodobenzylguanidine ([123I]mIBG) imaging. However, [123I]mIBG is associated with low image spatial resolution and sensitivity in cardiac imaging. We investigated the capability of an F-18-labeled mIBG derivative, meta-(3-[18F]fluoropropyl)benzylguanidine ([18F]mFPBG), for identifying ischemic and viable myocardium in a rat model of myocardial infarction. Materials and methods: The ex vivo biodistribution and in vivo metabolic stability of [18F]mFPBG were investigated in Sprague–Dawley rats. Selective cardiac adrenergic activation was confirmed via a blocking experiment involving pretreatment with desipramine (2 mg kg−1), followed by the administration of [18F]mFPBG. Imaging properties of [18F]mFPBG were compared with those of traditional cardiac imaging radiotracers ([123I]mIBG and [99mTc]MIBI) in a rat model of myocardial infarction. Non-invasive image-based measurements of infarct sizes were then compared with histological findings by using Bland–Altman analysis. Results: The differences in infarct sizes determined using histological analysis and [18F]mFPBG PET were −2.55 ± 4.99% (range: −12.33 to 7.22), −2.35 ± 3.32% (range: −8.87 to 4.16), and −3.15 ± 6.16% (range: −15.24 to 8.93) at 5, 20, and 40 min, respectively. Furthermore, [18F]mFPBG PET was superior to traditional imaging methods in assessing the degree of ischemia in areas of myocardial infarction, as well as the actual infarct size. Conclusion: Compared to [123I]mIBG, [18F]mFPBG showed improved spatial resolution and sensitivity in a rat model of myocardial infarction. This result suggested that [18F]mFPBG is a promising cardiac PET imaging agent for potential diagnostic application in PET cardiology.
Original language | English |
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Pages (from-to) | 63-70 |
Number of pages | 8 |
Journal | Nuclear Medicine and Biology |
Volume | 61 |
DOIs | |
State | Published - Jun 2018 |
Bibliographical note
Funding Information:This study was supported by the Health Technology R&D Project through Korea Health Industry Development Institute (KHIDI) grants ( HI14C1072 and HI16C0947 ) funded by the Ministry of Health & Welfare (MOHW) of the Korean Government , and National R&D Program through the Korea Institute of Radiological and Medical Sciences funded by the Ministry of Science, ICT & Future Planning (No. 1711045543 , 1711045539 ).
Publisher Copyright:
© 2018 Elsevier Inc.
Keywords
- F
- Cardiac sympathetic innervation
- Guanidine
- Myocardial infarction
- PET