Fasting glucose level and the risk of incident osteoporosis in the Koreans

Sung Keun Park, Ju Young Jung, Chang Mo Oh, Joong Myung Choi, Min Ho Kim, Eunhee Ha, Jae Hong Ryoo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose/Introduction: Conflicting results have been published regarding the effect of abnormal glucose metabolism on osteoporosis (AGM). Fasting glucose is a reliable indicator for abnormal glucose metabolism. Therefore, the aim of present study is to identify the association of fasting glucose level with the risk of incident osteoporosis. Methods: In a cohort of 59,936 men and 36,690 women (mean age of 63.9 ± 7.1 years) registered in national health insurance database, we assessed the risk of incident osteoporosis according to the quartile levels of baseline fasting glucose (quartile 1: <88 mg/dL, quartile 2: 88–96 mg/dL, quartile 3: 97–107 mg/dL and quartile 4: ≥108 mg/dL) and glycemic status categorized into normal, impaired fasting glucose (IFG) and diabetes mellitus (DM). Multivariate Cox-proportional hazard model was used in calculating adjusted hazard ratios (HRs) and 95% confidence interval (CI) for incident osteoporosis (adjusted HRs [95% CI]). Results: Compared with first quartile (reference), the risk of osteoporosis significantly decreased above the fourth quartile in men (second quartile: 1.04 [0.91–1.18], third quartile: 0.88 (0.76–1.00) and fourth quartile: 0.80 [0.70–0.92]) and above third quartile in women (second quartile: 0.95 [0.90–1.01], third quartile: 0.91 [0.86–0.97] and fourth quartile: 0.82 [0.77–0.88]). The risk of osteoporosis was less associated with IFG (men: 0.84 [0.76–0.94] and women: 0.93 [0.89–0.98]) and DM (men: 0.77 [0.65–0.91] and women: 0.75 [0.69–0.81]) than normal glucose group in both men and women. Conclusion: Our results suggest that elevated fasting glucose potentially associated with the decreased risk of osteoporosis. Mini-abstract: This retrospective study investigated the association between fasting glucose level and incidence of osteoporosis. Our findings indicate that elevated fasting glucose is significantly associated with the decreased risk of osteoporosis.

Original languageEnglish
Article number115690
JournalBone
Volume142
DOIs
StatePublished - Jan 2021

Bibliographical note

Funding Information:
We used the National Health Insurance Service?National Sample Cohort database and the dataset was obtained from the National Health Insurance Service. Our study findings were not related to the National Health Insurance Service. Sung Keun Park (first author); Writing- Original draft preparation, Writing- Reviewing and Editing, Data analysis. Ju Young Jung; English editing, Data curation. Chang-Mo Oh; Investigation, Writing- Reviewing and Editing, Data validation. Joong-Myung Choi; Supervision. Min-Ho Kim; Data analysis, Data curation. Eunhee Ha; Supervision, Conceptulization. Jae-Hong Ryoo (corresponding author); Conceptualization, Methodology, Data analysis, Data validation, Software.

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • Diabetes mellitus
  • Fasting glucose
  • Impaired fasting glucose
  • Osteoporosis

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