TY - JOUR
T1 - Fast tool for evaluation of iliac crest tissue elastic properties using the reduced-basis methods
AU - Lee, Taeyong
AU - Garlapati, Revanth Reddy
AU - Lam, Kathy
AU - Lee, Peter Vee Sin
AU - Chung, Yoon Sok
AU - Choi, Jae Bong
AU - Vincent, Tan Beng Chye
AU - Das De, Shamal
PY - 2010/11/9
Y1 - 2010/11/9
N2 - Computationally expensive finite element (FE) methods are generally used for indirect evaluation of tissue mechanical properties of trabecular specimens, which is vital for fracture risk prediction in the elderly. This work presents the application of reduced-basis (RB) methods for rapid evaluation of simulation results. Three cylindrical transiliac crest specimens (diameter: 7.5 mm, length: 10-12 mm) were obtained from healthy subjects (20 year-old, 22 year-old, and 24 year-old females) and scanned using microcomputed tomography imaging. Cubic samples of dimensions 5×5×5 mm3 were extracted from the core of the cylindrical specimens for FE analysis. Subsequently, a FE solution library (test space) was constructed for each of the specimens by varying the material property parameters: tissue elastic modulus and Poisson's ratio, to develop RB algorithms. The computational speed gain obtained by the RB methods and their accuracy relative to the FE analysis were evaluated. Speed gains greater than 4000 times, were obtained for all three specimens for a loss in accuracy of less than 1% in the maxima of von-Mises stress with respect to the FE-based value. The computational time decreased from more than 6 h to less than 18 s. RB algorithms can be successfully utilized for real-time reliable evaluation of trabecular bone elastic properties.
AB - Computationally expensive finite element (FE) methods are generally used for indirect evaluation of tissue mechanical properties of trabecular specimens, which is vital for fracture risk prediction in the elderly. This work presents the application of reduced-basis (RB) methods for rapid evaluation of simulation results. Three cylindrical transiliac crest specimens (diameter: 7.5 mm, length: 10-12 mm) were obtained from healthy subjects (20 year-old, 22 year-old, and 24 year-old females) and scanned using microcomputed tomography imaging. Cubic samples of dimensions 5×5×5 mm3 were extracted from the core of the cylindrical specimens for FE analysis. Subsequently, a FE solution library (test space) was constructed for each of the specimens by varying the material property parameters: tissue elastic modulus and Poisson's ratio, to develop RB algorithms. The computational speed gain obtained by the RB methods and their accuracy relative to the FE analysis were evaluated. Speed gains greater than 4000 times, were obtained for all three specimens for a loss in accuracy of less than 1% in the maxima of von-Mises stress with respect to the FE-based value. The computational time decreased from more than 6 h to less than 18 s. RB algorithms can be successfully utilized for real-time reliable evaluation of trabecular bone elastic properties.
KW - Computational speed gain
KW - Elastic property
KW - Finite element methods
KW - Iliac crest trabeculae
KW - Reduced-basis method
UR - http://www.scopus.com/inward/record.url?scp=78649405777&partnerID=8YFLogxK
U2 - 10.1115/1.4001254
DO - 10.1115/1.4001254
M3 - Article
C2 - 21142323
AN - SCOPUS:78649405777
SN - 0148-0731
VL - 132
JO - Journal of Biomechanical Engineering
JF - Journal of Biomechanical Engineering
IS - 12
M1 - 121009
ER -