Fast Degradable Polycaprolactone for Drug Delivery

Seo Hee Chang, Hyun Jung Lee, Sohee Park, Yelin Kim, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide-co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a fast degradable PCL while maintaining its crystalline properties and low melting point of PCL. The in vivo application of the paclitaxel-loaded PCL-OX microspheres provided a steady plasma drug concentration of 6-9 μg/mL over 28 days, similar to that of the PLGA microspheres. Both PCL and PLGA microspheres were completely cleared two months after in vivo implantation. The PCL-OX microspheres showed a similar tissue compatibility to that of PLGA microspheres in the subcutaneous layer of rats. These findings suggest that PCL-OX is a useful biomaterial that solves the slow degradation problems of PCL and, thus, may find uses in other biomedical applications as an alternative to PLGA.

Original languageEnglish
Pages (from-to)2302-2307
Number of pages6
JournalBiomacromolecules
Volume19
Issue number6
DOIs
StatePublished - 11 Jun 2018

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