Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Sang Jip Nam, Hyunsil Ko, Mihee Shin, Jungyeob Ham, Jungwook Chin, Youngshin Kim, Heeyoung Kim, Kyoungjin Shin, Hyukjae Choi, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

Original languageEnglish
Pages (from-to)5398-5402
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number20
DOIs
StatePublished - 15 Oct 2006

Keywords

  • Farnesoid X-activated receptor
  • Guggulsterone
  • Hypercholesterolemia
  • Marine sponge
  • Scalarane sesterterpene

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