Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Sang Jip Nam; Hyunsil Ko; Mihee Shin; Jungyeob Ham; Jungwook Chin; Youngshin Kim; Heeyoung Kim; Kyoungjin Shin; Hyukjae Choi; Heonjoong Kang

doi:10.1016/j.bmcl.2006.07.079

Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Sang Jip Nam, Hyunsil Ko, Mihee Shin, Jungyeob Ham, Jungwook Chin, Youngshin Kim, Heeyoung Kim, Kyoungjin Shin, Hyukjae Choi, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

Original language	English
Pages (from-to)	5398-5402
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2006.07.079
State	Published - 15 Oct 2006

Bibliographical note

Funding Information:
S. Nam, H. Ko, K. Shin, J. Chin, and H, Choi were in part supported by the BK21 program, Ministry of Education and Human Resources. This work was supported by the MarineBio 21 Program, Ministry of Maritime Affairs and Fisheries, Korea.

Keywords

Farnesoid X-activated receptor
Guggulsterone
Hypercholesterolemia
Marine sponge
Scalarane sesterterpene

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10.1016/j.bmcl.2006.07.079

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title = "Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.",

abstract = "Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.",

keywords = "Farnesoid X-activated receptor, Guggulsterone, Hypercholesterolemia, Marine sponge, Scalarane sesterterpene",

author = "Nam, {Sang Jip} and Hyunsil Ko and Mihee Shin and Jungyeob Ham and Jungwook Chin and Youngshin Kim and Heeyoung Kim and Kyoungjin Shin and Hyukjae Choi and Heonjoong Kang",

note = "Funding Information: S. Nam, H. Ko, K. Shin, J. Chin, and H, Choi were in part supported by the BK21 program, Ministry of Education and Human Resources. This work was supported by the MarineBio 21 Program, Ministry of Maritime Affairs and Fisheries, Korea.",

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doi = "10.1016/j.bmcl.2006.07.079",

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T1 - Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

AU - Nam, Sang Jip

AU - Ko, Hyunsil

AU - Shin, Mihee

AU - Ham, Jungyeob

AU - Chin, Jungwook

AU - Kim, Youngshin

AU - Kim, Heeyoung

AU - Shin, Kyoungjin

AU - Choi, Hyukjae

AU - Kang, Heonjoong

N1 - Funding Information: S. Nam, H. Ko, K. Shin, J. Chin, and H, Choi were in part supported by the BK21 program, Ministry of Education and Human Resources. This work was supported by the MarineBio 21 Program, Ministry of Maritime Affairs and Fisheries, Korea.

PY - 2006/10/15

Y1 - 2006/10/15

N2 - Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

AB - Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

KW - Farnesoid X-activated receptor

KW - Guggulsterone

KW - Hypercholesterolemia

KW - Marine sponge

KW - Scalarane sesterterpene

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IS - 20

ER -

Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Abstract

Bibliographical note

Keywords

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