Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.

Sang Jip Nam, Hyunsil Ko, Mihee Shin, Jungyeob Ham, Jungwook Chin, Youngshin Kim, Heeyoung Kim, Kyoungjin Shin, Hyukjae Choi, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.

Original languageEnglish
Pages (from-to)5398-5402
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number20
DOIs
StatePublished - 15 Oct 2006

Bibliographical note

Funding Information:
S. Nam, H. Ko, K. Shin, J. Chin, and H, Choi were in part supported by the BK21 program, Ministry of Education and Human Resources. This work was supported by the MarineBio 21 Program, Ministry of Maritime Affairs and Fisheries, Korea.

Keywords

  • Farnesoid X-activated receptor
  • Guggulsterone
  • Hypercholesterolemia
  • Marine sponge
  • Scalarane sesterterpene

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