@article{bc87c13d745d4b039b02dfb50732be37,
title = "Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.",
abstract = "Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.",
keywords = "Farnesoid X-activated receptor, Guggulsterone, Hypercholesterolemia, Marine sponge, Scalarane sesterterpene",
author = "Nam, {Sang Jip} and Hyunsil Ko and Mihee Shin and Jungyeob Ham and Jungwook Chin and Youngshin Kim and Heeyoung Kim and Kyoungjin Shin and Hyukjae Choi and Heonjoong Kang",
note = "Funding Information: S. Nam, H. Ko, K. Shin, J. Chin, and H, Choi were in part supported by the BK21 program, Ministry of Education and Human Resources. This work was supported by the MarineBio 21 Program, Ministry of Maritime Affairs and Fisheries, Korea.",
year = "2006",
month = oct,
day = "15",
doi = "10.1016/j.bmcl.2006.07.079",
language = "English",
volume = "16",
pages = "5398--5402",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "20",
}