Family income, cumulative risk exposure, and white matter structure in middle childhood

Alexander J. Dufford, Pilyoung Kim

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Family income is associated with gray matter morphometry in children, but little is known about the relationship between family income and white matter structure. In this paper, using Tract-Based Spatial Statistics, a whole brain, voxel-wise approach, we examined the relationship between family income (assessed by income-to-needs ratio) and white matter organization in middle childhood (N D 27, M D 8.66 years). Results from a non-parametric, voxel-wise, multiple regression (threshold-free cluster enhancement, p < 0.05 FWE corrected) indicated that lower family income was associated with lower white matter organization [assessed by fractional anisotropy (FA)] for several clusters in white matter tracts involved in cognitive and emotional functions including frontolimbic circuitry (uncinate fasciculus and cingulum bundle), association fibers (inferior longitudinal fasciculus, superior longitudinal fasciculus), and corticospinal tracts. Further, we examined the possibility that cumulative risk (CR) exposure might function as one of the potential pathways by which family income influences neural outcomes. Using multiple regressions, we found lower FA in portions of these tracts, including those found in the left cingulum bundle and left superior longitudinal fasciculus, was significantly related to greater exposure to CR (β= -0.47, p < 0.05 and β = -0.45, p < 0.05).

Original languageEnglish
Article number547
JournalFrontiers in Human Neuroscience
Volume11
DOIs
StatePublished - 13 Nov 2017

Bibliographical note

Funding Information:
This work was supported by the National Institute of Child Health and Human Development [R21HD078797; R01 HD090068]; the Professional Research Opportunity for Faculty (PROF) and Faculty Research Fund (FRF), University of Denver; and the Victoria S. Levin Award for Early Career Success in Young Children’s Mental Health Research, Society for Research in Child Development (SRCD).

Publisher Copyright:
© 2017 Dufford and Kim.

Keywords

  • Cumulative risk
  • Diffusion tensor imaging (DTI)
  • Family income
  • Middle childhood
  • White matter

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