Factors influencing culture positivity in pyogenic vertebral osteomyelitis patients with prior antibiotic exposure

Chung Jong Kim, Seung Ji Kang, Doran Yoon, Myung Jin Lee, Moonsuk Kim, Kyoung Ho Song, Hee Chang Jang, Sook In Jung, Eu Suk Kim, Hong Bin Kim, Myoung Don Oh, Kyung Hwa Park, Nam Joong Kim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 days (range, 0.7 to 5.7 days). In a multivariate analysis, a higher C-reactive protein (CRP) level (adjusted odds ratio [aOR], 1.18; 95% confidence interval, 1.07 to 1.29) and open surgical biopsy (aOR, 6.33; 95% confidence interval, 1.12 to 35.86) were associated with tissue culture positivity.

Original languageEnglish
Pages (from-to)2470-2473
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number4
DOIs
StatePublished - 1 Apr 2015

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