TY - JOUR
T1 - Factors associated with failure of high-flow nasal cannula
AU - Kim, Beong Ki
AU - Kim, Sua
AU - Kim, Chi Young
AU - Cha, Jaehyung
AU - Lee, Young Seok
AU - Ko, Yousang
AU - Kwack, Won Gun
AU - Park, So Young
AU - Kim, Je Hyeong
N1 - Publisher Copyright:
© 2020 Daedalus Enterprises.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - BACKGROUND: The use of high-flow nasal cannula (HFNC) is rapidly increasing without clear indications, creating the potential for overuse or misuse and the accompanying risk of adverse events. The purpose of this study was to determine the factors associated with HFNC failure by examining the current clinical practice of HFNC. METHODS: From July 1, 2017, to June 30, 2018, in 5 university-affiliated hospitals in the Republic of Korea, a total of 1,161 admitted adult subjects who had HFNC administered were retrospectively enrolled and their medical records were reviewed. RESULTS: Pulmonary diseases including pneumonia (n = 757, 65.2%) were the most common reason for use of HFNC. Subjects with do-not-resuscitate (DNR) or do-not-intubate (DNI) orders comprised 33.8% of the study population (n = 392); 563 subjects (48.5%) were escalated directly to HFNC from low-flow devices without applying reservoir or other high-flow devices. In the non-DNR/DNI subjects, arterial blood gas was not monitored in 15.2% and 14.8% of subjects before and after HFNC application, respectively, and it was not monitored in 28.0% just before HFNC weaning. The HFNC failure rate was 27.0% in non-DNR/DNI subjects, and the HFNC failure was significantly associated with the decision by residents to apply HFNC (odds ratio [OR] 2.03, 95% CI 1.29–3.18, P =.002), high breathing frequency (OR 1.07, 95% CI 1.04–1.10, P <.001) ≤ 6 h before HFNC application, low SaO2 (OR 0.92, 95% CI 0.89–0.95, P <.001) ≤ 6 h before HFNC application, low SpO2 (OR 0.95, 95% CI 0.93–0.98, P <.001) ≤ 6 h before HFNC application, and the ratio of SpO2 /FIO2 to breathing frequency (ROX index) ≤ 6 h after HFNC application (OR 0.88, 95% CI 0.84–0.92, P<.001). CONCLUSIONS: HFNC was practiced without applying reservoir or other high-flow devices before application and without appropriate arterial blood gas monitoring during HFNC therapy. HFNC failure was significantly associated with the decision by the resident to use HFNC, breathing frequency, SaO2, and SpO2 ≤ 6 h before HFNC application, and with the ROX index ≤ 6 h after HFNC application.
AB - BACKGROUND: The use of high-flow nasal cannula (HFNC) is rapidly increasing without clear indications, creating the potential for overuse or misuse and the accompanying risk of adverse events. The purpose of this study was to determine the factors associated with HFNC failure by examining the current clinical practice of HFNC. METHODS: From July 1, 2017, to June 30, 2018, in 5 university-affiliated hospitals in the Republic of Korea, a total of 1,161 admitted adult subjects who had HFNC administered were retrospectively enrolled and their medical records were reviewed. RESULTS: Pulmonary diseases including pneumonia (n = 757, 65.2%) were the most common reason for use of HFNC. Subjects with do-not-resuscitate (DNR) or do-not-intubate (DNI) orders comprised 33.8% of the study population (n = 392); 563 subjects (48.5%) were escalated directly to HFNC from low-flow devices without applying reservoir or other high-flow devices. In the non-DNR/DNI subjects, arterial blood gas was not monitored in 15.2% and 14.8% of subjects before and after HFNC application, respectively, and it was not monitored in 28.0% just before HFNC weaning. The HFNC failure rate was 27.0% in non-DNR/DNI subjects, and the HFNC failure was significantly associated with the decision by residents to apply HFNC (odds ratio [OR] 2.03, 95% CI 1.29–3.18, P =.002), high breathing frequency (OR 1.07, 95% CI 1.04–1.10, P <.001) ≤ 6 h before HFNC application, low SaO2 (OR 0.92, 95% CI 0.89–0.95, P <.001) ≤ 6 h before HFNC application, low SpO2 (OR 0.95, 95% CI 0.93–0.98, P <.001) ≤ 6 h before HFNC application, and the ratio of SpO2 /FIO2 to breathing frequency (ROX index) ≤ 6 h after HFNC application (OR 0.88, 95% CI 0.84–0.92, P<.001). CONCLUSIONS: HFNC was practiced without applying reservoir or other high-flow devices before application and without appropriate arterial blood gas monitoring during HFNC therapy. HFNC failure was significantly associated with the decision by the resident to use HFNC, breathing frequency, SaO2, and SpO2 ≤ 6 h before HFNC application, and with the ROX index ≤ 6 h after HFNC application.
KW - High-flow nasal cannula
KW - Hypoxia
KW - Oxygen inhalation therapy
KW - Respiratory insufficiency
UR - http://www.scopus.com/inward/record.url?scp=85090279865&partnerID=8YFLogxK
U2 - 10.4187/respcare.07403
DO - 10.4187/respcare.07403
M3 - Article
C2 - 32209713
AN - SCOPUS:85090279865
SN - 0020-1324
VL - 65
SP - 1276
EP - 1284
JO - Respiratory Care
JF - Respiratory Care
IS - 9
ER -