Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

Luling Wu; Chusen Huang; Ben P. Emery; Adam C. Sedgwick; Steven D. Bull; Xiao Peng He; He Tian; Juyoung Yoon; Jonathan L. Sessler; Tony D. James

doi:10.1039/c9cs00318e

Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

Luling Wu
, Chusen Huang
, Ben P. Emery
, Adam C. Sedgwick
, Steven D. Bull
, Xiao Peng He
, He Tian
, Juyoung Yoon
, Jonathan L. Sessler
, Tony D. James

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

951 Scopus citations

Abstract

In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying energy donor-acceptor dye combinations and emphasise their applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvionments and dual/multi-analyte responsive systems.

Original language	English
Pages (from-to)	5110-5139
Number of pages	30
Journal	Chemical Society Reviews
Volume	49
Issue number	15
DOIs	https://doi.org/10.1039/c9cs00318e
State	Published - 7 Aug 2020

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© The Royal Society of Chemistry.

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@article{c3963802fb2240a6bc06102ec742a7dd,

title = "F{\"o}rster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents",

abstract = "In this tutorial review, we will explore recent advances in the construction and application of F{\"o}rster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying energy donor-acceptor dye combinations and emphasise their applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvionments and dual/multi-analyte responsive systems.",

author = "Luling Wu and Chusen Huang and Emery, \{Ben P.\} and Sedgwick, \{Adam C.\} and Bull, \{Steven D.\} and He, \{Xiao Peng\} and He Tian and Juyoung Yoon and Sessler, \{Jonathan L.\} and James, \{Tony D.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2020",

month = aug,

day = "7",

doi = "10.1039/c9cs00318e",

language = "English",

volume = "49",

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journal = "Chemical Society Reviews",

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TY - JOUR

T1 - Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

AU - Wu, Luling

AU - Huang, Chusen

AU - Emery, Ben P.

AU - Sedgwick, Adam C.

AU - Bull, Steven D.

AU - He, Xiao Peng

AU - Tian, He

AU - Yoon, Juyoung

AU - Sessler, Jonathan L.

AU - James, Tony D.

PY - 2020/8/7

Y1 - 2020/8/7

N2 - In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying energy donor-acceptor dye combinations and emphasise their applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvionments and dual/multi-analyte responsive systems.

AB - In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying energy donor-acceptor dye combinations and emphasise their applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvionments and dual/multi-analyte responsive systems.

UR - https://www.scopus.com/pages/publications/85089129763

U2 - 10.1039/c9cs00318e

DO - 10.1039/c9cs00318e

M3 - Review article

C2 - 32697225

AN - SCOPUS:85089129763

SN - 0306-0012

VL - 49

SP - 5110

EP - 5139

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 15

ER -

Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

Abstract

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