Eye-Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins

Byeongho Park, Seokyoung Bang, Kyeong Seob Hwang, Yeon Kyung Cha, Jisung Kwak, Na Ly Tran, Hyo Suk Kim, Subeen Park, Seung Ja Oh, Maesoon Im, Sooyoung Chung, Jongbaeg Kim, Tai Hyun Park, Hyun Seok Song, Hong Nam Kim, Jae Hun Kim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


An in vitro model, composed of the short-wavelength human opsins and rhodopsins, is created. Two types of photosensitive neural spheroids are transfected for selective reaction under bluish-purple and green lights. These are employed to two devices with intact neuron and neural-spheroid to study the interaction. By photostimulation, the photosensitive spheroid initiated photoactivation, and the signal generated from its body is transmitted to adjacent neural networks. Specifically, the signal traveled through the axon bundle in narrow gap from photosensitive spheroid to intact spheroid as an eye-to-brain model including optic nerve. The whole process with photosensitive spheroid is monitored by calcium ion detecting fluorescence images. The results of this study can be applied to examine vision restoration and novel photosensitive biological systems with spectral sensitivity.

Original languageEnglish
Article number2302996
JournalAdvanced Materials
Issue number35
StatePublished - 1 Sep 2023

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© 2023 Wiley-VCH GmbH.


  • biological mimicking
  • human opsin proteins
  • neural networks
  • photosensitive cells
  • spheroids


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