Extranigral extension of structural midbrain lesions overshadows parkinsonism

Hee Jin Kim; Ji Young Yun; Jong Min Kim; Yu Kyeong Kim; Gwanhee Erm; Sang Eun Kim; Beom S. Jeon

doi:10.1007/s00702-011-0584-y

Extranigral extension of structural midbrain lesions overshadows parkinsonism

Hee Jin Kim, Ji Young Yun, Jong Min Kim, Yu Kyeong Kim, Gwanhee Erm, Sang Eun Kim, Beom S. Jeon

Department of Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

We report on a clinicoanatomical analysis of five patients with structural midbrain lesions who shared severe nigrostriatal dopaminergic denervation but presented different involuntary movements. The main clinical phenotype was parkinsonism in only one case; it was choreoballism in three cases and tremor and dystonia in one case. Structural midbrain lesions are likely to involve structures additional to nigral dopaminergic neurons. The extent of extranigral involvement may determine the diverse clinical manifestations associated with the structural midbrain lesions.

Original language	English
Pages (from-to)	1209-1213
Number of pages	5
Journal	Journal of Neural Transmission
Volume	118
Issue number	8
DOIs	https://doi.org/10.1007/s00702-011-0584-y
State	Published - Aug 2011

Keywords

Chorea
Dopamine transporter imaging
Dystonia
Midbrain
Parkinsonism

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10.1007/s00702-011-0584-y

Cite this

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title = "Extranigral extension of structural midbrain lesions overshadows parkinsonism",

abstract = "We report on a clinicoanatomical analysis of five patients with structural midbrain lesions who shared severe nigrostriatal dopaminergic denervation but presented different involuntary movements. The main clinical phenotype was parkinsonism in only one case; it was choreoballism in three cases and tremor and dystonia in one case. Structural midbrain lesions are likely to involve structures additional to nigral dopaminergic neurons. The extent of extranigral involvement may determine the diverse clinical manifestations associated with the structural midbrain lesions.",

keywords = "Chorea, Dopamine transporter imaging, Dystonia, Midbrain, Parkinsonism",

author = "Kim, {Hee Jin} and Yun, {Ji Young} and Kim, {Jong Min} and Kim, {Yu Kyeong} and Gwanhee Erm and Kim, {Sang Eun} and Jeon, {Beom S.}",

note = "Funding Information: This study was supported by a grant of Seoul National University Hospital (03-2008-015). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. HJK and BSJ had had full access to the data in the study and had final responsibility for the decision to submit for publication. ",

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doi = "10.1007/s00702-011-0584-y",

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AU - Kim, Hee Jin

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AU - Kim, Jong Min

AU - Kim, Yu Kyeong

AU - Erm, Gwanhee

AU - Kim, Sang Eun

AU - Jeon, Beom S.

N1 - Funding Information: This study was supported by a grant of Seoul National University Hospital (03-2008-015). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. HJK and BSJ had had full access to the data in the study and had final responsibility for the decision to submit for publication.

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AB - We report on a clinicoanatomical analysis of five patients with structural midbrain lesions who shared severe nigrostriatal dopaminergic denervation but presented different involuntary movements. The main clinical phenotype was parkinsonism in only one case; it was choreoballism in three cases and tremor and dystonia in one case. Structural midbrain lesions are likely to involve structures additional to nigral dopaminergic neurons. The extent of extranigral involvement may determine the diverse clinical manifestations associated with the structural midbrain lesions.

KW - Chorea

KW - Dopamine transporter imaging

KW - Dystonia

KW - Midbrain

KW - Parkinsonism

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Extranigral extension of structural midbrain lesions overshadows parkinsonism

Abstract

Keywords

UN SDGs

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