Extracellular vesicles as potential therapeutics for inflammatory diseases

Hee Sook Hwang, Hyosuk Kim, Geonhee Han, Jong Won Lee, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.

Original languageEnglish
Article number5487
JournalInternational Journal of Molecular Sciences
Issue number11
StatePublished - 1 Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Biomarker
  • EV engineering
  • Extracellular vesicle
  • Inflammatory disease


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