Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.
Bibliographical noteFunding Information:
This study was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408), Brain Pool Program (NRF-2020H1D3A1A02081401) and Intramural Research Program of Korea Institute of Science and Technology (KIST).
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- EV engineering
- Extracellular vesicle
- Inflammatory disease