Extracellular vesicles as potential theranostic platforms for skin diseases and aging

Hyosuk Kim, Jong Won Lee, Geonhee Han, Kwangmeyung Kim, Yoosoo Yang, Sun Hwa Kim

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Extracellular vesicles (EVs), naturally secreted by cells, act as mediators for communication between cells. They are transported to the recipient cells along with cargoes such as nucleic acids, proteins, and lipids that reflect the changes occurring within the parent cells. Thus, EVs have been recognized as potential theranostic agents for diagnosis, treatment, and prognosis. In particular, the evidence accumulated to date suggests an important role of EVs in the initiation and progression of skin aging and various skin diseases, including psoriasis, systemic lupus erythematosus, vitiligo, and chronic wounds. This review highlights recent research that investigates the role of EVs and their potential as biomarkers and therapeutic agents for skin diseases and aging.

Original languageEnglish
Article number760
Issue number5
StatePublished - May 2021

Bibliographical note

Funding Information:
This work was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408) and the Intramural Research Program of Korea Institute of Science and Technology (KIST).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Biomarker
  • Extracellular vesicles
  • Skin aging
  • Skin disease
  • Therapy


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