Extracellular potassium deprivation reversibly dephosphorylates cofilin

Jaehoon Jung, Heejin Park, Moonhee Kim, Min Jeong Kim, Eung Chil Choi, Kyunglim Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Cofilin is essential for actin filament remodeling in various cell types. We previously reported that ouabain leads to dephosphorylation of cofilin, resulting in cytoskeletal reorganization and cell volume change. We report here that the extracellular [K+]e deprivation causes dephosphorylation of cofilin with disruption of cytoskeletal structures and cell shrinkage. These changes can be reversed by time-dependent restoration of [K+]e. Thus, these results suggest that the acute shift of [K+]e triggers a reversible change of cofilin phosphorylation which may be an essential event in the regulation of cytoskeletal architecture and cell volume.

Original languageEnglish
Pages (from-to)1393-1397
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - 14 Jul 2006

Bibliographical note

Funding Information:
This work was supported by Korea Research Foundation Grant funded by Korea Government (MOEHRD, Basic Research Promotion Fund), Korean Health 21 R&D Project, Ministry of Health and Welfare (A050402), and the Korea Science and Engineering Foundation through CCSR at Ewha Womans University.


  • [K] (extracellular potassium concentration)
  • Cell volume
  • Cofilin
  • Cytoskeleton
  • Phosphorylation


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