Extracellular potassium deprivation reversibly dephosphorylates cofilin

Jaehoon Jung; Heejin Park; Moonhee Kim; Min Jeong Kim; Eung Chil Choi; Kyunglim Lee

doi:10.1016/j.bbrc.2006.05.028

Extracellular potassium deprivation reversibly dephosphorylates cofilin

Jaehoon Jung, Heejin Park, Moonhee Kim, Min Jeong Kim, Eung Chil Choi, Kyunglim Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Cofilin is essential for actin filament remodeling in various cell types. We previously reported that ouabain leads to dephosphorylation of cofilin, resulting in cytoskeletal reorganization and cell volume change. We report here that the extracellular [K⁺]_e deprivation causes dephosphorylation of cofilin with disruption of cytoskeletal structures and cell shrinkage. These changes can be reversed by time-dependent restoration of [K⁺]_e. Thus, these results suggest that the acute shift of [K⁺]_e triggers a reversible change of cofilin phosphorylation which may be an essential event in the regulation of cytoskeletal architecture and cell volume.

Original language	English
Pages (from-to)	1393-1397
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	345
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2006.05.028
State	Published - 14 Jul 2006

Bibliographical note

Funding Information:
This work was supported by Korea Research Foundation Grant funded by Korea Government (MOEHRD, Basic Research Promotion Fund), Korean Health 21 R&D Project, Ministry of Health and Welfare (A050402), and the Korea Science and Engineering Foundation through CCSR at Ewha Womans University.

Keywords

[K] (extracellular potassium concentration)
Cell volume
Cofilin
Cytoskeleton
Phosphorylation

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10.1016/j.bbrc.2006.05.028

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title = "Extracellular potassium deprivation reversibly dephosphorylates cofilin",

abstract = "Cofilin is essential for actin filament remodeling in various cell types. We previously reported that ouabain leads to dephosphorylation of cofilin, resulting in cytoskeletal reorganization and cell volume change. We report here that the extracellular [K+]e deprivation causes dephosphorylation of cofilin with disruption of cytoskeletal structures and cell shrinkage. These changes can be reversed by time-dependent restoration of [K+]e. Thus, these results suggest that the acute shift of [K+]e triggers a reversible change of cofilin phosphorylation which may be an essential event in the regulation of cytoskeletal architecture and cell volume.",

keywords = "[K] (extracellular potassium concentration), Cell volume, Cofilin, Cytoskeleton, Phosphorylation",

author = "Jaehoon Jung and Heejin Park and Moonhee Kim and Kim, {Min Jeong} and Choi, {Eung Chil} and Kyunglim Lee",

note = "Funding Information: This work was supported by Korea Research Foundation Grant funded by Korea Government (MOEHRD, Basic Research Promotion Fund), Korean Health 21 R&D Project, Ministry of Health and Welfare (A050402), and the Korea Science and Engineering Foundation through CCSR at Ewha Womans University. ",

year = "2006",

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doi = "10.1016/j.bbrc.2006.05.028",

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AU - Jung, Jaehoon

AU - Park, Heejin

AU - Kim, Moonhee

AU - Kim, Min Jeong

AU - Choi, Eung Chil

AU - Lee, Kyunglim

N1 - Funding Information: This work was supported by Korea Research Foundation Grant funded by Korea Government (MOEHRD, Basic Research Promotion Fund), Korean Health 21 R&D Project, Ministry of Health and Welfare (A050402), and the Korea Science and Engineering Foundation through CCSR at Ewha Womans University.

PY - 2006/7/14

Y1 - 2006/7/14

N2 - Cofilin is essential for actin filament remodeling in various cell types. We previously reported that ouabain leads to dephosphorylation of cofilin, resulting in cytoskeletal reorganization and cell volume change. We report here that the extracellular [K+]e deprivation causes dephosphorylation of cofilin with disruption of cytoskeletal structures and cell shrinkage. These changes can be reversed by time-dependent restoration of [K+]e. Thus, these results suggest that the acute shift of [K+]e triggers a reversible change of cofilin phosphorylation which may be an essential event in the regulation of cytoskeletal architecture and cell volume.

AB - Cofilin is essential for actin filament remodeling in various cell types. We previously reported that ouabain leads to dephosphorylation of cofilin, resulting in cytoskeletal reorganization and cell volume change. We report here that the extracellular [K+]e deprivation causes dephosphorylation of cofilin with disruption of cytoskeletal structures and cell shrinkage. These changes can be reversed by time-dependent restoration of [K+]e. Thus, these results suggest that the acute shift of [K+]e triggers a reversible change of cofilin phosphorylation which may be an essential event in the regulation of cytoskeletal architecture and cell volume.

KW - [K] (extracellular potassium concentration)

KW - Cell volume

KW - Cofilin

KW - Cytoskeleton

KW - Phosphorylation

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Extracellular potassium deprivation reversibly dephosphorylates cofilin

Abstract

Bibliographical note

Keywords

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