Expression of translationally controlled tumor protein mRNA in human colon cancer

Sookhee Chung, Miyoung Kim, Won Ja Choi, June Key Chung, Kyunglim Lee

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependent expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and their tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalCancer Letters
Volume156
Issue number2
DOIs
StatePublished - 11 Aug 2000

Keywords

  • Colon cancer
  • Northern blot
  • Translationally controlled tumor protein
  • Xenografted tumor
  • Yeast cell cycle

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