Expression of translationally controlled tumor protein mRNA in human colon cancer

Sookhee Chung; Miyoung Kim; Won Ja Choi; June Key Chung; Kyunglim Lee

doi:10.1016/S0304-3835(00)00460-2

Expression of translationally controlled tumor protein mRNA in human colon cancer

Sookhee Chung, Miyoung Kim, Won Ja Choi, June Key Chung, Kyunglim Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependent expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and their tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	185-190
Number of pages	6
Journal	Cancer Letters
Volume	156
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00460-2
State	Published - 11 Aug 2000

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation through the Center for Cell Signaling Research at Ewha Woman's University, by the Korea Research Foundation, and by the Brain Korea 21 Project.

Keywords

Colon cancer
Northern blot
Translationally controlled tumor protein
Xenografted tumor
Yeast cell cycle

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10.1016/S0304-3835(00)00460-2

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title = "Expression of translationally controlled tumor protein mRNA in human colon cancer",

abstract = "The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependent expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and their tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Colon cancer, Northern blot, Translationally controlled tumor protein, Xenografted tumor, Yeast cell cycle",

author = "Sookhee Chung and Miyoung Kim and Choi, {Won Ja} and Chung, {June Key} and Kyunglim Lee",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation through the Center for Cell Signaling Research at Ewha Woman's University, by the Korea Research Foundation, and by the Brain Korea 21 Project.",

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doi = "10.1016/S0304-3835(00)00460-2",

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T1 - Expression of translationally controlled tumor protein mRNA in human colon cancer

AU - Chung, Sookhee

AU - Kim, Miyoung

AU - Choi, Won Ja

AU - Chung, June Key

AU - Lee, Kyunglim

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation through the Center for Cell Signaling Research at Ewha Woman's University, by the Korea Research Foundation, and by the Brain Korea 21 Project.

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Y1 - 2000/8/11

N2 - The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependent expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and their tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependent expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and their tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Colon cancer

KW - Northern blot

KW - Translationally controlled tumor protein

KW - Xenografted tumor

KW - Yeast cell cycle

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Expression of translationally controlled tumor protein mRNA in human colon cancer

Abstract

Bibliographical note

Keywords

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