Expression of Rh glycoproteins in the mammalian kidney

Ki Hwan Han, Hye Young Kim, L. David Weiner

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Ammonia metabolism is a fundamental process in the maintenance of life in all living organisms. Recent studies have identified ammonia transporter family proteins in yeast (Mep), plants (Amt), and mammals (Rh glycoproteins). In mammalian kidneys, where ammonia metabolism and transport are critically important for the regulation of systemic acid-base homeostasis, basolateral Rh B glycoprotein and apical/basolateral Rh C glycoprotein are expressed along the distal nephron segments. Data from experimental animal models and knockout mice suggest that the Rh glycoproteins appear to mediate important roles in urinary ammonia excretion.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalElectrolyte and Blood Pressure
Issue number1
StatePublished - Jun 2009


  • Ammonia
  • Collecting
  • Kidney
  • Kidney tubules


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