Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation

Ed Laufer, Randall Dahn, Olivia E. Orozco, Chang Yeol Yeo, Jacqueline Pisenti, Domingos Henrique, Ursula K. Abbott, John F. Fallon, Cliff Tabin

Research output: Contribution to journalArticlepeer-review

230 Scopus citations

Abstract

The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb, its formation is directed by the boundary between cells that do end cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-I in the ventral ectoderm.

Original languageEnglish
Pages (from-to)366-373
Number of pages8
JournalNature
Volume386
Issue number6623
DOIs
StatePublished - 27 Mar 1997

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