Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone

So Yeon Shim, Han Suk Kim, Ee Kyung Kim, Jung Hwan Choi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Peroxiredoxins (Prdx), a family of antioxidant proteins, have important defensive roles in the degenerative brain diseases and neuronal cell death in adult subjects. However, little is known in the neonatal brain. Here, we studied the developmental expression of Prdxs and their response to dexamethasone in the perinatal rat brain. Prdx 1 expression increased during late gestations and peaked at postnatal-day 1, when its expression gradually decreased. Prdx 2 expression remained largely unchanged. Prdx 6 expression continually increased as growing. Using immunohistochemistry, each Prdx showed a strong expression in the cerebral cortex and hippocampus. Prdx 1 was strongly expressed in the corpus callosum. The dexamethasone injection increased the expression of Prdx 6. In conclusion, we reveal for the first time that Prdx 1, 2 and 6 are found in abundance in the perinatal rat brain and are differentially expressed during development. The expression of Prdx 6 was affected by dexamethasone treatment.

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalFree Radical Research
Issue number3
StatePublished - Mar 2012

Bibliographical note

Funding Information:
This study was supported by a grant from Department of Pediatrics, Seoul National University College of Medicine (No. 05-01).


  • Antioxidant
  • Development
  • Dexamethasone
  • Peroxiredoxin
  • Rat brain


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