Expression of bone morphogenetic protein receptors type-IA, -IB, and -II correlates with tumor grade in human prostate cancer tissues

Isaac Yi Kim, Dong Hyeon Lee, Han Jong Ahn, Hideo Tokunaga, Weitao Song, Lisa M. Devereaux, Donald Jin, T. Kuber Sampath, Ronald A. Morton

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Bone morphogenetic proteins (BMPs) are potential regulators of prostate cancer cell growth and metastasis that signal through an interaction with BMP membrane receptors (BMPRs) type I and type II. In the present study, Western blot and immunohistochemical analysis of BMPRs were carried out in benign and malignant human prostate tissues to explain the loss of BMP response in human prostate cancer cells. The results demonstrated that the benign prostate specimens expressed high levels of all three BMPRs. In normal prostate, BMPRs were localized predominantly to epithelial cells. Among prostate cancer specimens, well-differentiated cancers were positive for the expression of BMPR-II, BMPR-IA, and BMPR-IB, for the most part. In contrast, only 1 of 10 poorly differentiated prostate cancer cases was positive for each of the three BMPRs (P < 0.005 for all three receptors). Taken together, these results indicate that human prostate cancer cells frequently exhibit loss of expression of BMPRs and suggest that loss of BMPRs may play an important role during the progression of prostate cancer.

Original languageEnglish
Pages (from-to)2840-2844
Number of pages5
JournalCancer Research
Volume60
Issue number11
StatePublished - 1 Jun 2000

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