Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis

Minyoung Jung, Insung Kim, Ji Young Lee, Hyun Mi Kim, Mijeong Kwon, Minjeong Kim, Kyung Min Lim, Peter S. Kim, Kangmo Ahn, Jihyun Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD). Methods: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. We also measured filaggrin and FDPs from the volar surface of the forearm. Results: In AD patients, skin temperature on the forearm decreased after exposure to the conventional and wind-free modes (P < 0.001 and P = 0.026), and TEWL on the cheek and the forearm decreased in the wind-free mode (P = 0.037 and 0.002). Skin pH on the cheek increased only after exposure to the conventional mode in AD group (P = 0.002). However, no changes in TEWL and skin pH were found after exposure to either the conventional or the wind-free mode in the control group. In AD children, the levels of pyrrolidone carboxylic acid (PCA) and cis-urocanic acid (UCA) were reduced only after exposure to the conventional mode (all P = 0.033). The percent changes of PCA and cis-UCA were higher in the AD group than those in the control group after exposure to conventional mode (P = 0.029 and 0.046). Conclusions: Skin barrier function in children with AD may be altered by the exposure to cold airflow from a conventional air conditioner.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalAllergology International
Volume69
Issue number3
DOIs
StatePublished - Jul 2020

Keywords

  • Air movements
  • Atopic dermatitis
  • Environmental impact
  • Filaggrin
  • Wind

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