In an effort to explore a multifunctional dye, we investigated the spectroscopic properties of a benzofuran-based fluorophore, (E)-3-(6-(diethylamino) benzofuran-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (DABP). We found that DABP shows a strong solvatrochromic effect in aprotic solvents and the excited-state intramolecular proton transfer (ESIPT) in protic solvents. We measured the fluorescence lifetime of DABP in different solvents and discovered that its lifetime decreases dramatically because of strong hydrogen bonding. One remarkable feature of the DABP emission is its high sensitivity to water content. We utilized this property to detect amyloid oligomers and observed that DABP is highly sensitive toward early-stage amyloid aggregates.
|Number of pages||5|
|Journal||Bulletin of the Korean Chemical Society|
|State||Published - 1 Apr 2016|
- Charge transfer
- Electron transfer