Experimental murine fascioliasis derives early immune suppression with increased levels of TGF-β and IL-4

Joon Yong Chung, Young An Bae, Doo Hee Yun, Hyun Jong Yang, Yoon Kong

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 postinfection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes signifcantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalThe Korean journal of parasitology
Volume50
Issue number4
DOIs
StatePublished - Dec 2012

Keywords

  • Fasciola hepatica
  • IL-4
  • Murine fascioliasis
  • T-lymphocyte
  • TGF-β

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