Experimental and Theoretical Structural Characterization of Cu-Au Tripods for Photothermal Anticancer Therapy

Sitansu Sekhar Nanda; K. P.S.S. Hembram; Jae Kap Lee; Kwangmeyung Kim; Subramanian Tamil Selvan; Dong Kee Yi

doi:10.1021/acsanm.9b00634

Experimental and Theoretical Structural Characterization of Cu-Au Tripods for Photothermal Anticancer Therapy

Sitansu Sekhar Nanda, K. P.S.S. Hembram, Jae Kap Lee, Kwangmeyung Kim, Subramanian Tamil Selvan, Dong Kee Yi

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Anisotropic metal nanostructures (e.g., Au-Ag, Au-Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu-Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu-Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu₃Au, Cu-Au, and CuAu₃ and confirmed that their stability in the following order: CuAu₃ < Cu-Au < Cu₃Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.

Original language	English
Pages (from-to)	3735-3742
Number of pages	8
Journal	ACS Applied Nano Materials
Volume	2
Issue number	6
DOIs	https://doi.org/10.1021/acsanm.9b00634
State	Published - 28 Jun 2019

Bibliographical note

Funding Information:
This work was supported by the Korean National Research Foundation (NRF-2018R1A2B6007786). The Server Farm Supercomputing Facility at Korea Institute of Science and Technology is also acknowledged.

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

bimetallic nanocrystals
cancer cells
Cu-Au tripods
NIR laser
photothermal therapy

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10.1021/acsanm.9b00634

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title = "Experimental and Theoretical Structural Characterization of Cu-Au Tripods for Photothermal Anticancer Therapy",

abstract = "Anisotropic metal nanostructures (e.g., Au-Ag, Au-Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu-Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu-Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu-Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu-Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.",

keywords = "bimetallic nanocrystals, cancer cells, Cu-Au tripods, NIR laser, photothermal therapy",

author = "Nanda, {Sitansu Sekhar} and Hembram, {K. P.S.S.} and Lee, {Jae Kap} and Kwangmeyung Kim and Selvan, {Subramanian Tamil} and Yi, {Dong Kee}",

note = "Funding Information: This work was supported by the Korean National Research Foundation (NRF-2018R1A2B6007786). The Server Farm Supercomputing Facility at Korea Institute of Science and Technology is also acknowledged. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = jun,

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doi = "10.1021/acsanm.9b00634",

language = "English",

volume = "2",

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T1 - Experimental and Theoretical Structural Characterization of Cu-Au Tripods for Photothermal Anticancer Therapy

AU - Nanda, Sitansu Sekhar

AU - Hembram, K. P.S.S.

AU - Lee, Jae Kap

AU - Kim, Kwangmeyung

AU - Selvan, Subramanian Tamil

AU - Yi, Dong Kee

N1 - Funding Information: This work was supported by the Korean National Research Foundation (NRF-2018R1A2B6007786). The Server Farm Supercomputing Facility at Korea Institute of Science and Technology is also acknowledged. Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Anisotropic metal nanostructures (e.g., Au-Ag, Au-Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu-Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu-Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu-Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu-Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.

AB - Anisotropic metal nanostructures (e.g., Au-Ag, Au-Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu-Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu-Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu-Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu-Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.

KW - bimetallic nanocrystals

KW - cancer cells

KW - Cu-Au tripods

KW - NIR laser

KW - photothermal therapy

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U2 - 10.1021/acsanm.9b00634

DO - 10.1021/acsanm.9b00634

M3 - Article

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JO - ACS Applied Nano Materials

JF - ACS Applied Nano Materials

IS - 6

ER -

Experimental and Theoretical Structural Characterization of Cu-Au Tripods for Photothermal Anticancer Therapy

Abstract

Bibliographical note

Keywords

UN SDGs

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