Expanding roles of centrosome abnormalities in cancers

Soohyun Song, Surim Jung, Mijung Kwon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Centrosome abnormalities are hallmarks of human cancers. Structural and numerical centrosome abnormalities correlate with tumor aggressiveness and poor prognosis, implicating that centrosome abnormalities could be a cause of tumorigenesis. Since Boveri made his pioneering recognition of the potential causal link between centrosome abnormalities and cancer more than a century ago, there has been significant progress in the field. Here, we review recent advances in the understanding of the causes and consequences of centrosome abnormalities and their connection to cancers. Centrosome abnormalities can drive the initiation and progression of cancers in multiple ways. For example, they can generate chromosome instability through abnormal mitosis, accelerating cancer genome evolution. Remarkably, it is becoming clear that the mechanisms by which centrosome abnormalities promote several steps of tumorigenesis are far beyond what Boveri had initially envisioned. We highlight various cancer-promoting mechanisms exerted by cells with centrosome abnormalities and how these cells possessing oncogenic potential can be monitored.

Original languageEnglish
Pages (from-to)216-224
Number of pages9
JournalBMB Reports
Volume56
Issue number4
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 by the The Korean Society for Biochemistry and Molecular Biology

Keywords

  • Cancer
  • Cell cycle
  • Centrosome
  • Genome instability
  • Invasion

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