Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer

Maria Beecher, Namrata Kumar, Sunbok Jang, Vesna Rapić-Otrin, Bennett Van Houten

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

UV-damaged DNA binding protein (UV-DDB) is a heterodimeric complex, composed of DDB1 and DDB2, and is involved in global genome nucleotide excision repair. Mutations in DDB2 are associated with xeroderma pigmentosum complementation group E. UV-DDB forms a ubiquitin E3 ligase complex with cullin-4A and RBX that helps to relax chromatin around UV-induced photoproducts through the ubiquitination of histone H2A. After providing a brief historical perspective on UV-DDB, we review our current knowledge of the structure and function of this intriguing repair protein. Finally, this article discusses emerging data suggesting that UV-DDB may have other non-canonical roles in base excision repair and the etiology of cancer.

Original languageEnglish
Article number102860
JournalDNA Repair
Volume94
DOIs
StatePublished - Oct 2020

Keywords

  • Nucleotide excision repair
  • Single molecule
  • Structure-function
  • UV-DDB
  • Xeroderma pigmentosum
  • XP-E

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