Exosome-specific dual-patterned immuno-filtration (EXODIF) devices for the rapid capture and efficient release of circulating exosome from cancer patients' blood

Y. T. Kang, Y. J. Kim, J. Bu, I. Doh, Y. H. Cho, S. W. Han, B. I. Moon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present a microfluidics device for the capture and release of circulating exosome from blood. The EXODIF, composed of two distinct immuno-patterned layers, is capable to enhance binding chance between antibody and exosome and generates mechanical whirling; thus achieving high-throughput and specific exosome isolation. The device performance was verified using blood from cancer patients and healthy donors, revealed that cancer patient show significantly higher exosome level compared to healthy donors after electron microscopy and nanoparticle tracking analysis. This simple and fast exosome isolation is appropriate for exosome-based cancer diagnostics and may help to elucidate the function of exosome in cancer.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages317-318
Number of pages2
ISBN (Electronic)9780979806490
StatePublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016

Publication series

Name20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Conference

Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Country/TerritoryIreland
CityDublin
Period9/10/1613/10/16

Bibliographical note

Funding Information:
This research was supported by the Converging Research Center Program funded by the Ministry of Science, ICT and Future Planning (Project No. 2015054201)

Keywords

  • Cancer
  • Dual immuno-patterns
  • Exosome
  • Extracellular vesicles
  • Isolations

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