Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

Adam C. Sedgwick, Luling Wu, Hai Hao Han, Steven D. Bull, Xiao Peng He, Tony D. James, Jonathan L. Sessler, Ben Zhong Tang, He Tian, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

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Abstract

In this review we will explore recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based sensors and imaging agents (probes) are important in biology, physiology, pharmacology, and environmental science for the selective detection of biologically and/or environmentally important species. The development of ESIPT-based fluorescence probes is particularly attractive due to their unique properties, which include a large Stokes shift, environmental sensitivity and potential for ratiometric sensing.

Original languageEnglish
Pages (from-to)8842-8880
Number of pages39
JournalChemical Society Reviews
Volume47
Issue number23
DOIs
StatePublished - 7 Dec 2018

Bibliographical note

Funding Information:
Luling Wu received his MSc in 2017 from Shanghai Normal University. In 2017, he was awarded a scholarship by the China Scholarship Council (CSC) to carry out a PhD at the University of Bath. Tony D. James is a Professor at the University of Bath, Fellow of the Royal Society of Chemistry and holds a Royal Society Wolfson Research Merit Award (2017–2022). His BSc was from the University of East Anglia (1986), PhD from the University of Victoria (1991), Postdoctoral Research with Seiji Shinkai (1991–1995) and Royal Society University Research Fellow at the University of Birmingham (1995–2000). He was awarded the Daiwa-Adrian Prize (2013), the inaugural CASE Prize (2015) and MSMLG Czarnik Award (2018). Steven D. Bull received a BSc Joint Hons from the

Funding Information:
ACS thanks the EPSRC for a studentship. LW wishes to thank China Scholarship Council and the University of Bath for supporting his PhD work in the UK. ACS, LW, SDB and TDJ would like to thank the EPSRC and the University of Bath for funding. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and Sophia University for a visiting professorship. HHH, XPH, HT thank the Natural Science Foundation of China (No. 21788102, 21722801 and 21572058), the Program of Introducing Talents of Discipline to Universities (B16017) and the Shanghai Rising-Star Program (16QA1401400) (XPH) for generous financial support. BZT thanks the National Natural Science Foundation of China (21788102) and the Innovation and Technology Commission of Hong Kong (ITC-CNERC14SC01) for financial support. JY acknowledges a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). JLS thanks the National Institutes of Health (RGM103790A) and the Robert A. Welch Foundation (F-0018) for support. We would like to

Funding Information:
ACS thanks the EPSRC for a studentship. LW wishes to thank China Scholarship Council and the University of Bath for supporting his PhD work in the UK. ACS, LW, SDB and TDJ would like to thank the EPSRC and the University of Bath for funding. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and Sophia University for a visiting professorship. HHH, XPH, HT thank the Natural Science Foundation of China (No. 21788102, 21722801 and 21572058), the Program of Introducing Talents of Discipline to Universities (B16017) and the Shanghai Rising-Star Program (16QA1401400) (XPH) for generous financial support. BZT thanks the National Natural Science Foundation of China (21788102) and the Innovation and Technology Commission of Hong Kong (ITCCNERC14SC01) for financial support. JY acknowledges a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2012R1A3A2048814). JLS thanks the National Institutes of Health (RGM103790A) and the Robert A. Welch Foundation (F-0018) for support. We would like to thank Lauren Gwynne and Bethany L. Patenall for proof reading the manuscript.

Publisher Copyright:
© The Royal Society of Chemistry 2018

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