Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

Adam C. Sedgwick, Luling Wu, Hai Hao Han, Steven D. Bull, Xiao Peng He, Tony D. James, Jonathan L. Sessler, Ben Zhong Tang, He Tian, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

866 Scopus citations


In this review we will explore recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based sensors and imaging agents (probes) are important in biology, physiology, pharmacology, and environmental science for the selective detection of biologically and/or environmentally important species. The development of ESIPT-based fluorescence probes is particularly attractive due to their unique properties, which include a large Stokes shift, environmental sensitivity and potential for ratiometric sensing.

Original languageEnglish
Pages (from-to)8842-8880
Number of pages39
JournalChemical Society Reviews
Issue number23
StatePublished - 7 Dec 2018


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