@inproceedings{07882b8659bd48078bf1c45ab7761613,
title = "Examining cytotoxic effects on single cells using an impedance spectroscopic platform",
abstract = "We present a microfluidic device for performing impedance spectroscopic analyses of the steady-state and time-transient response of single cells exposed to cytotoxic agents and drug compounds. This platform is capable of long-term label-free assays. Sample preparation steps normally associated with fluorescence analysis (fixing, staining and washing) are avoided. We analysed the transient impedance from single cells to study the kinetics of cell response to Streptolysin-O (SLO) on mammalian cells. The toxin was found to cause a gradual decrease in the impedance, which corresponded to an increase in membrane conductivity. Increasing concentrations of toxins caused a higher rate of change seen as an overall decrease in the impedance.",
keywords = "Impedance Spectroscopy, Label Free Method, Single Cell Analysis",
author = "Daniele Malleo and {Tanner Nevill}, J. and {Di Carlo}, Dino and Lee, {Luke P.} and Hywel Morgan",
note = "Publisher Copyright: {\textcopyright} 2007 CBMS.; 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 ; Conference date: 07-10-2007 Through 11-10-2007",
year = "2007",
language = "English",
series = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",
publisher = "Chemical and Biological Microsystems Society",
pages = "1083--1085",
editor = "Jean-Louis Viovy and Patrick Tabeling and Stephanie Descroix and Laurent Malaquin",
booktitle = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",
}