Evidence based guidelines for the treatment of helicobacter pylori infection in Korea 2020

Korean College of Helicobacter and Upper Gastrointesinal Research

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9 Scopus citations


pylori infection is one of the most common infectious diseases world­wide. H. pylori is responsible for substantial gastrointestinal morbidity with a high disease burden. Since the revision of the H. pylori Clinical Practice Guide­lines in 2013 in Korea, the eradication rate of H. pylori has gradually decreased with the use of a clarithromycin based triple therapy. According to a nationwide randomized controlled study by the Korean College of Helicobacter and Upper Gastrointestinal Research released in 2018, the intention-to-treat eradication rate was only 63.9%, which was mostly due to increased antimicrobial resistance to clarithromycin. The clinical practice guidelines for treatment of H. pylori were updated based on evidence-based medicine from a meta-analysis conducted on a target group receiving the latest level of eradication therapy. The draft recom­mendations developed based on the meta-analysis were finalized after expert consensus on three recommendations regarding the indication for treatment and eight recommendations on the treatment itself. These guidelines were designed to provide clinical evidence for the treatment of H. pylori to patients, nurses, medical school students, policymakers, and clinicians. These may differ from current medical insurance standards, and will be revised if more evidence emerges in the future.

Original languageEnglish
Pages (from-to)807-838
Number of pages32
JournalKorean Journal of Internal Medicine
Issue number4
StatePublished - Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 The Korean Association of Internal Medicine.


  • Guidelines
  • Helicobacter pylori
  • Meta-analysis
  • Microbial sensitivity tests
  • Treatment


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