Evaluation on the P-glycoprotein inhibitory activity of Indonesian medicinal plants

Eun Jung Go; Hyang Rim Kim; Soo Yeon Chung; Yeon Hee Jeong; Na Hyung Kim; Ah Reum Han; Eun Kyoung Seo; Hwa Jeong Lee

Evaluation on the P-glycoprotein inhibitory activity of Indonesian medicinal plants

Eun Jung Go, Hyang Rim Kim, Soo Yeon Chung, Yeon Hee Jeong, Na Hyung Kim, Ah Reum Han, Eun Kyoung Seo, Hwa Jeong Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

One hundred Indonesian plant extracts were screened to investigate their effects on the P-glycoprotein (P-gp) activity in human uterine sarcoma cells, MES-SA/DX5, for the first time. Among others, four samples, Alpinia galanga (BuOH ext.), Sindora sumatrana (CHCl₃ ext.), Strychnos ligustrina (CHCl₃ ext.), and Zingiber cassumunar Roxb (hexane ext.), exhibited the most potent inhibition on the P-gp activity. They increased cytotoxic activity of daunomycin up to IC₅₀ values of less than 1.41 μM, which is a value with a positive control, verapamil. Other 25 samples showed significant P-gp inhibitory activity with IC₅₀ values between 1.4 and 4.0 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	Natural Product Sciences
Volume	10
Issue number	2
State	Published - Apr 2004

Keywords

Indonesian plants
Multidrug resistance
P-glycoprotein

Cite this

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title = "Evaluation on the P-glycoprotein inhibitory activity of Indonesian medicinal plants",

abstract = "One hundred Indonesian plant extracts were screened to investigate their effects on the P-glycoprotein (P-gp) activity in human uterine sarcoma cells, MES-SA/DX5, for the first time. Among others, four samples, Alpinia galanga (BuOH ext.), Sindora sumatrana (CHCl3 ext.), Strychnos ligustrina (CHCl3 ext.), and Zingiber cassumunar Roxb (hexane ext.), exhibited the most potent inhibition on the P-gp activity. They increased cytotoxic activity of daunomycin up to IC50 values of less than 1.41 μM, which is a value with a positive control, verapamil. Other 25 samples showed significant P-gp inhibitory activity with IC50 values between 1.4 and 4.0 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.",

keywords = "Indonesian plants, Multidrug resistance, P-glycoprotein",

author = "Go, {Eun Jung} and Kim, {Hyang Rim} and Chung, {Soo Yeon} and Jeong, {Yeon Hee} and Kim, {Na Hyung} and Han, {Ah Reum} and Seo, {Eun Kyoung} and Lee, {Hwa Jeong}",

year = "2004",

month = apr,

language = "English",

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pages = "85--88",

journal = "Natural Product Sciences",

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TY - JOUR

T1 - Evaluation on the P-glycoprotein inhibitory activity of Indonesian medicinal plants

AU - Go, Eun Jung

AU - Kim, Hyang Rim

AU - Chung, Soo Yeon

AU - Jeong, Yeon Hee

AU - Kim, Na Hyung

AU - Han, Ah Reum

AU - Seo, Eun Kyoung

AU - Lee, Hwa Jeong

PY - 2004/4

Y1 - 2004/4

N2 - One hundred Indonesian plant extracts were screened to investigate their effects on the P-glycoprotein (P-gp) activity in human uterine sarcoma cells, MES-SA/DX5, for the first time. Among others, four samples, Alpinia galanga (BuOH ext.), Sindora sumatrana (CHCl3 ext.), Strychnos ligustrina (CHCl3 ext.), and Zingiber cassumunar Roxb (hexane ext.), exhibited the most potent inhibition on the P-gp activity. They increased cytotoxic activity of daunomycin up to IC50 values of less than 1.41 μM, which is a value with a positive control, verapamil. Other 25 samples showed significant P-gp inhibitory activity with IC50 values between 1.4 and 4.0 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

AB - One hundred Indonesian plant extracts were screened to investigate their effects on the P-glycoprotein (P-gp) activity in human uterine sarcoma cells, MES-SA/DX5, for the first time. Among others, four samples, Alpinia galanga (BuOH ext.), Sindora sumatrana (CHCl3 ext.), Strychnos ligustrina (CHCl3 ext.), and Zingiber cassumunar Roxb (hexane ext.), exhibited the most potent inhibition on the P-gp activity. They increased cytotoxic activity of daunomycin up to IC50 values of less than 1.41 μM, which is a value with a positive control, verapamil. Other 25 samples showed significant P-gp inhibitory activity with IC50 values between 1.4 and 4.0 μM. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

KW - Indonesian plants

KW - Multidrug resistance

KW - P-glycoprotein

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M3 - Article

AN - SCOPUS:2542488306

SN - 1226-3907

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SP - 85

EP - 88

JO - Natural Product Sciences

JF - Natural Product Sciences

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ER -

Evaluation on the P-glycoprotein inhibitory activity of Indonesian medicinal plants

Abstract

Keywords

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