Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos

Yoshihiro Uto; Dai Tamatani; Yusuke Mizuki; Yoshio Endo; Ikuo Nakanishi; Kei Ohkubo; Shunichi Fukuzumi; Masahiro Ishizuka; Tohru Tanaka; Daisuke Kuchiike; Kentaro Kubo; Toshio Inui; Hitoshi Hori

Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos

Yoshihiro Uto, Dai Tamatani, Yusuke Mizuki, Yoshio Endo, Ikuo Nakanishi, Kei Ohkubo, Shunichi Fukuzumi, Masahiro Ishizuka, Tohru Tanaka, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Hitoshi Hori

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Recently, 5-aminolevulinic acid (5-ALA), precursors of protoporphyrin IX (PpIX), and Sn(IV) chlorin e6 (SnCe6) have been proposed as possible sonosensitizers for sonodynamic therapy of cancer. Therefore, we evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in vivo by using the EMT6/KU tumor-bearing chick embryos. Results: The concentration of PpIX in tumor and liver tissues and serum increased in a time-dependent manner after the i.v. administration of 5-ALA; PpIX concentrations reached their peak level after 5-7 h. The concentration of SnCe6 reached its maximum value in the tumor tissue and serum immediately after i.v. administration. The combined treatment of 5-ALA or SnCe6 with ultrasound irradiation showed a significant antitumor effect towards EMT6/KU solid tumors. Conclusion: We evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in a chick embryo model and found that 5-ALA might be more suitable as a sonosensitizer than SnCe6.

Original language	English
Pages (from-to)	4583-4588
Number of pages	6
Journal	Anticancer Research
Volume	34
Issue number	8
State	Published - 1 Aug 2014

Bibliographical note

Publisher Copyright:
© 2014, International Institute of Anticancer Research. All rights reserved.

Keywords

5-aminolevulinic acid
Pharmacokinetics
Sn(IV) chlorin e6
Sonosensitizer
Tumor-bearing chick embryo

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{99916e9a6ff94585a86615f73ad6045f,

title = "Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos",

abstract = "Background: Recently, 5-aminolevulinic acid (5-ALA), precursors of protoporphyrin IX (PpIX), and Sn(IV) chlorin e6 (SnCe6) have been proposed as possible sonosensitizers for sonodynamic therapy of cancer. Therefore, we evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in vivo by using the EMT6/KU tumor-bearing chick embryos. Results: The concentration of PpIX in tumor and liver tissues and serum increased in a time-dependent manner after the i.v. administration of 5-ALA; PpIX concentrations reached their peak level after 5-7 h. The concentration of SnCe6 reached its maximum value in the tumor tissue and serum immediately after i.v. administration. The combined treatment of 5-ALA or SnCe6 with ultrasound irradiation showed a significant antitumor effect towards EMT6/KU solid tumors. Conclusion: We evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in a chick embryo model and found that 5-ALA might be more suitable as a sonosensitizer than SnCe6.",

keywords = "5-aminolevulinic acid, Pharmacokinetics, Sn(IV) chlorin e6, Sonosensitizer, Tumor-bearing chick embryo",

author = "Yoshihiro Uto and Dai Tamatani and Yusuke Mizuki and Yoshio Endo and Ikuo Nakanishi and Kei Ohkubo and Shunichi Fukuzumi and Masahiro Ishizuka and Tohru Tanaka and Daisuke Kuchiike and Kentaro Kubo and Toshio Inui and Hitoshi Hori",

year = "2014",

month = aug,

day = "1",

language = "English",

volume = "34",

pages = "4583--4588",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "8",

}

TY - JOUR

T1 - Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos

AU - Uto, Yoshihiro

AU - Tamatani, Dai

AU - Mizuki, Yusuke

AU - Endo, Yoshio

AU - Nakanishi, Ikuo

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

AU - Ishizuka, Masahiro

AU - Tanaka, Tohru

AU - Kuchiike, Daisuke

AU - Kubo, Kentaro

AU - Inui, Toshio

AU - Hori, Hitoshi

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Background: Recently, 5-aminolevulinic acid (5-ALA), precursors of protoporphyrin IX (PpIX), and Sn(IV) chlorin e6 (SnCe6) have been proposed as possible sonosensitizers for sonodynamic therapy of cancer. Therefore, we evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in vivo by using the EMT6/KU tumor-bearing chick embryos. Results: The concentration of PpIX in tumor and liver tissues and serum increased in a time-dependent manner after the i.v. administration of 5-ALA; PpIX concentrations reached their peak level after 5-7 h. The concentration of SnCe6 reached its maximum value in the tumor tissue and serum immediately after i.v. administration. The combined treatment of 5-ALA or SnCe6 with ultrasound irradiation showed a significant antitumor effect towards EMT6/KU solid tumors. Conclusion: We evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in a chick embryo model and found that 5-ALA might be more suitable as a sonosensitizer than SnCe6.

AB - Background: Recently, 5-aminolevulinic acid (5-ALA), precursors of protoporphyrin IX (PpIX), and Sn(IV) chlorin e6 (SnCe6) have been proposed as possible sonosensitizers for sonodynamic therapy of cancer. Therefore, we evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in vivo by using the EMT6/KU tumor-bearing chick embryos. Results: The concentration of PpIX in tumor and liver tissues and serum increased in a time-dependent manner after the i.v. administration of 5-ALA; PpIX concentrations reached their peak level after 5-7 h. The concentration of SnCe6 reached its maximum value in the tumor tissue and serum immediately after i.v. administration. The combined treatment of 5-ALA or SnCe6 with ultrasound irradiation showed a significant antitumor effect towards EMT6/KU solid tumors. Conclusion: We evaluated the pharmacokinetic properties and sonosensitizing activities of 5-ALA and SnCe6 in a chick embryo model and found that 5-ALA might be more suitable as a sonosensitizer than SnCe6.

KW - 5-aminolevulinic acid

KW - Pharmacokinetics

KW - Sn(IV) chlorin e6

KW - Sonosensitizer

KW - Tumor-bearing chick embryo

UR - http://www.scopus.com/inward/record.url?scp=84908676250&partnerID=8YFLogxK

M3 - Article

C2 - 25075103

AN - SCOPUS:84908676250

SN - 0250-7005

VL - 34

SP - 4583

EP - 4588

JO - Anticancer Research

JF - Anticancer Research

IS - 8

ER -

Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos

Abstract

Bibliographical note

Keywords

UN SDGs

Fingerprint

Cite this