Abstract
The relationship between histopathologic characteristics and treatment outcomes in patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab-based immunochemotherapy needs re-evaluation. Patients with newly diagnosed DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) were evaluated with respect to clinical characteristics, treatment efficacy, and survival. Immunohistochemistry of bcl-2, CD10, bcl-6, and MUM-1 was performed and patients were sub-classified as germinal center B-cell-like (GCB) or non-GCB type according to the Hans algorithm. There was no significant difference in overall survival (OS) between patients with GCB and those with non-GCB. Although there was no significant difference in OS between high-intermediate and high risk groups as classified by the s andard International Prognostic Index (IPI; p=0.50), all three groups with the revised IPI had a clear-cut separation for event-free survival and OS. The revised IPI better predicted survival than did the standard IPI in patients with DLBCL treated with R-CHOP. The Hans classification had no prognostic value.
Original language | English |
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Pages (from-to) | 1904-1912 |
Number of pages | 9 |
Journal | Leukemia and Lymphoma |
Volume | 52 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2011 |
Keywords
- Diffuse large B-cell lymphoma
- immunochemotherapy
- immunohistochemistry
- prognosis
- rituximab