Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.
Bibliographical noteFunding Information:
This study was supported by the 2018 Yeungnam University Research Grant and by the Human Resources Program in Energy Technology of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) granted financial resource from the Ministry of Trade, Industry & Energy, Korea (No. 20174030201760).
© 2021, The Korean Society for Biotechnology and Bioengineering and Springer.
- bone graft
- composite scaffold