Abstract
Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.
Original language | English |
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Pages (from-to) | 201-207 |
Number of pages | 7 |
Journal | Biotechnology and Bioprocess Engineering |
Volume | 26 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2021 |
Keywords
- bone graft
- composite scaffold
- hydroxyapatite
- levan
- sintering