Evaluation of dry eye and meibomian gland dysfunction after cataract surgery

Kyung Eun Han; Sang Chul Yoon; Ji Min Ahn; Sang Min Nam; R. Doyle Stulting; Eung Kweon Kim; Kyoung Yul Seo

doi:10.1016/j.ajo.2014.02.036

Evaluation of dry eye and meibomian gland dysfunction after cataract surgery

Kyung Eun Han
, Sang Chul Yoon
, Ji Min Ahn
, Sang Min Nam
, R. Doyle Stulting
, Eung Kweon Kim
, Kyoung Yul Seo

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

167 Scopus citations

Abstract

• Purpose: To evaluate dry eye and meibomian gland dysfunction after cataract surgery. • Design: Prospective observational case series. • Methods: We studied 58 eyes of 48 patients who underwent phacoemulsification and evaluated them preoperatively and at 1 month and 3 months postoperatively. Ocular symptom scores, lid margin abnormalities, superficial punctate keratopathies (SPKs), tear film break-up time (TBUT), Schirmer test, lower tear meniscus height, depth, and area using Fourier domain optical coherence tomography, meibum expressibility and images of the meibomian glands using meibography were measured. • Results: The ocular symptom scores were worse at 1 month and 3 months postoperatively (P < 0.001 and P < 0.001, respectively). Lid margin abnormalities were significantly increased (P < 0.001 and P < 0.001, respectively) and TBUT decreased postoperatively (P < 0.001 and P < 0.001, respectively). Meibum expressibility decreased at 3 months postoperatively (P = 0.016); however, meibography score, SPK, lower tear meniscus height, depth and area and the Schirmer test did not change significantly postoperatively (all P values >0.05). • Conclusion: Meibomian gland function may be altered without accompanying structural changes after cataract surgery.

Original language	English
Pages (from-to)	1144-1150.e1
Journal	American Journal of Ophthalmology
Volume	157
Issue number	6
DOIs	https://doi.org/10.1016/j.ajo.2014.02.036
State	Published - Jun 2014

Bibliographical note

Funding Information:
All authors have completed and submitted the ICMJE form for disclosure for potential conflicts of interest, and none were reported. This study was supported by a grant from the Korea Healthcare technology R&D Project , Ministry of Health & Welfare , Republic of Korea (Grant No. A121861 ). Involved in design of study (K.E.H., K.Y.S); Conduct of study (K.E.H., S.C.Y., K.Y.S); Collection, management, analysis, and interpretation of data (K.E.H., S.C.Y., S.M.N., J.M.A., K.Y.S); Preparation of manuscript (K.E.H., K.Y.S); Critical revision of article; (K.E.H., S.M.N., R.D.S., K.Y.S.); Final approval of manuscript (K.E.H., R.D.S., E.K.K., K.Y.S).

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10.1016/j.ajo.2014.02.036

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@article{46f83008be5b4d84afafb6e83d63a599,

title = "Evaluation of dry eye and meibomian gland dysfunction after cataract surgery",

abstract = "• Purpose: To evaluate dry eye and meibomian gland dysfunction after cataract surgery. • Design: Prospective observational case series. • Methods: We studied 58 eyes of 48 patients who underwent phacoemulsification and evaluated them preoperatively and at 1 month and 3 months postoperatively. Ocular symptom scores, lid margin abnormalities, superficial punctate keratopathies (SPKs), tear film break-up time (TBUT), Schirmer test, lower tear meniscus height, depth, and area using Fourier domain optical coherence tomography, meibum expressibility and images of the meibomian glands using meibography were measured. • Results: The ocular symptom scores were worse at 1 month and 3 months postoperatively (P < 0.001 and P < 0.001, respectively). Lid margin abnormalities were significantly increased (P < 0.001 and P < 0.001, respectively) and TBUT decreased postoperatively (P < 0.001 and P < 0.001, respectively). Meibum expressibility decreased at 3 months postoperatively (P = 0.016); however, meibography score, SPK, lower tear meniscus height, depth and area and the Schirmer test did not change significantly postoperatively (all P values >0.05). • Conclusion: Meibomian gland function may be altered without accompanying structural changes after cataract surgery.",

author = "Han, \{Kyung Eun\} and Yoon, \{Sang Chul\} and Ahn, \{Ji Min\} and Nam, \{Sang Min\} and Stulting, \{R. Doyle\} and Kim, \{Eung Kweon\} and Seo, \{Kyoung Yul\}",

note = "Funding Information: All authors have completed and submitted the ICMJE form for disclosure for potential conflicts of interest, and none were reported. This study was supported by a grant from the Korea Healthcare technology R\&D Project , Ministry of Health \& Welfare , Republic of Korea (Grant No. A121861 ). Involved in design of study (K.E.H., K.Y.S); Conduct of study (K.E.H., S.C.Y., K.Y.S); Collection, management, analysis, and interpretation of data (K.E.H., S.C.Y., S.M.N., J.M.A., K.Y.S); Preparation of manuscript (K.E.H., K.Y.S); Critical revision of article; (K.E.H., S.M.N., R.D.S., K.Y.S.); Final approval of manuscript (K.E.H., R.D.S., E.K.K., K.Y.S). ",

year = "2014",

month = jun,

doi = "10.1016/j.ajo.2014.02.036",

language = "English",

volume = "157",

pages = "1144--1150.e1",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier Inc.",

number = "6",

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TY - JOUR

T1 - Evaluation of dry eye and meibomian gland dysfunction after cataract surgery

AU - Han, Kyung Eun

AU - Yoon, Sang Chul

AU - Ahn, Ji Min

AU - Nam, Sang Min

AU - Stulting, R. Doyle

AU - Kim, Eung Kweon

AU - Seo, Kyoung Yul

N1 - Funding Information: All authors have completed and submitted the ICMJE form for disclosure for potential conflicts of interest, and none were reported. This study was supported by a grant from the Korea Healthcare technology R&D Project , Ministry of Health & Welfare , Republic of Korea (Grant No. A121861 ). Involved in design of study (K.E.H., K.Y.S); Conduct of study (K.E.H., S.C.Y., K.Y.S); Collection, management, analysis, and interpretation of data (K.E.H., S.C.Y., S.M.N., J.M.A., K.Y.S); Preparation of manuscript (K.E.H., K.Y.S); Critical revision of article; (K.E.H., S.M.N., R.D.S., K.Y.S.); Final approval of manuscript (K.E.H., R.D.S., E.K.K., K.Y.S).

PY - 2014/6

Y1 - 2014/6

N2 - • Purpose: To evaluate dry eye and meibomian gland dysfunction after cataract surgery. • Design: Prospective observational case series. • Methods: We studied 58 eyes of 48 patients who underwent phacoemulsification and evaluated them preoperatively and at 1 month and 3 months postoperatively. Ocular symptom scores, lid margin abnormalities, superficial punctate keratopathies (SPKs), tear film break-up time (TBUT), Schirmer test, lower tear meniscus height, depth, and area using Fourier domain optical coherence tomography, meibum expressibility and images of the meibomian glands using meibography were measured. • Results: The ocular symptom scores were worse at 1 month and 3 months postoperatively (P < 0.001 and P < 0.001, respectively). Lid margin abnormalities were significantly increased (P < 0.001 and P < 0.001, respectively) and TBUT decreased postoperatively (P < 0.001 and P < 0.001, respectively). Meibum expressibility decreased at 3 months postoperatively (P = 0.016); however, meibography score, SPK, lower tear meniscus height, depth and area and the Schirmer test did not change significantly postoperatively (all P values >0.05). • Conclusion: Meibomian gland function may be altered without accompanying structural changes after cataract surgery.

AB - • Purpose: To evaluate dry eye and meibomian gland dysfunction after cataract surgery. • Design: Prospective observational case series. • Methods: We studied 58 eyes of 48 patients who underwent phacoemulsification and evaluated them preoperatively and at 1 month and 3 months postoperatively. Ocular symptom scores, lid margin abnormalities, superficial punctate keratopathies (SPKs), tear film break-up time (TBUT), Schirmer test, lower tear meniscus height, depth, and area using Fourier domain optical coherence tomography, meibum expressibility and images of the meibomian glands using meibography were measured. • Results: The ocular symptom scores were worse at 1 month and 3 months postoperatively (P < 0.001 and P < 0.001, respectively). Lid margin abnormalities were significantly increased (P < 0.001 and P < 0.001, respectively) and TBUT decreased postoperatively (P < 0.001 and P < 0.001, respectively). Meibum expressibility decreased at 3 months postoperatively (P = 0.016); however, meibography score, SPK, lower tear meniscus height, depth and area and the Schirmer test did not change significantly postoperatively (all P values >0.05). • Conclusion: Meibomian gland function may be altered without accompanying structural changes after cataract surgery.

UR - https://www.scopus.com/pages/publications/84901790785

U2 - 10.1016/j.ajo.2014.02.036

DO - 10.1016/j.ajo.2014.02.036

M3 - Article

C2 - 24561172

AN - SCOPUS:84901790785

SN - 0002-9394

VL - 157

SP - 1144-1150.e1

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 6

ER -

Evaluation of dry eye and meibomian gland dysfunction after cataract surgery

Abstract

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