Evaluation of DNA strand-scission activity of the Korean indigenous plants

Hye Young Choi; Ah Reum Han; Woongchon Mar; Eun Kyoung Seo

Evaluation of DNA strand-scission activity of the Korean indigenous plants

Hye Young Choi, Ah Reum Han, Woongchon Mar, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of IC₅₀<25 μg/ml. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with IC₅₀ values of 5.9 and 4.9 μg/ml, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.

Original language	English
Pages (from-to)	162-164
Number of pages	3
Journal	Natural Product Sciences
Volume	8
Issue number	4
State	Published - Dec 2002

Keywords

Caesalpinia sappan
DNA strand-scission
Mucuna birdwoodiana
Plant extracts

Cite this

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title = "Evaluation of DNA strand-scission activity of the Korean indigenous plants",

abstract = "The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of IC50<25 μg/ml. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with IC50 values of 5.9 and 4.9 μg/ml, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.",

keywords = "Caesalpinia sappan, DNA strand-scission, Mucuna birdwoodiana, Plant extracts",

author = "Choi, {Hye Young} and Han, {Ah Reum} and Woongchon Mar and Seo, {Eun Kyoung}",

year = "2002",

month = dec,

language = "English",

volume = "8",

pages = "162--164",

journal = "Natural Product Sciences",

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publisher = "Korean Society of Pharmacognosy",

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T1 - Evaluation of DNA strand-scission activity of the Korean indigenous plants

AU - Choi, Hye Young

AU - Han, Ah Reum

AU - Mar, Woongchon

AU - Seo, Eun Kyoung

PY - 2002/12

Y1 - 2002/12

N2 - The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of IC50<25 μg/ml. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with IC50 values of 5.9 and 4.9 μg/ml, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.

AB - The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of IC50<25 μg/ml. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with IC50 values of 5.9 and 4.9 μg/ml, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.

KW - Caesalpinia sappan

KW - DNA strand-scission

KW - Mucuna birdwoodiana

KW - Plant extracts

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M3 - Article

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SN - 1226-3907

VL - 8

SP - 162

EP - 164

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 4

ER -

Evaluation of DNA strand-scission activity of the Korean indigenous plants

Abstract

Keywords

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