Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells

Gowooni Park; Eun Jin Lee; Hye Young Min; Hye Young Choi; Ah Reum Han; Sang Kook Lee; Eun Kyoung Seo

Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells

Gowooni Park, Eun Jin Lee, Hye Young Min, Hye Young Choi, Ah Reum Han, Sang Kook Lee, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

One-hundred and twenty plant extracts were prepared from 29 cIndonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of ED₅₀<20 μg/ml. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with ED₅₀ values ranging from 0.25 to 0.46 μg/ml. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.

Original language	English
Pages (from-to)	165-169
Number of pages	5
Journal	Natural Product Sciences
Volume	8
Issue number	4
State	Published - Dec 2002

Keywords

Cytotoxicity
Indonesian plants
Plant extracts
Zingiber cassumunar

Cite this

@article{fe7d896fc4ec414e9201d08c20438e42,

title = "Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells",

abstract = "One-hundred and twenty plant extracts were prepared from 29 cIndonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of ED50<20 μg/ml. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with ED50 values ranging from 0.25 to 0.46 μg/ml. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.",

keywords = "Cytotoxicity, Indonesian plants, Plant extracts, Zingiber cassumunar",

author = "Gowooni Park and Lee, {Eun Jin} and Min, {Hye Young} and Choi, {Hye Young} and Han, {Ah Reum} and Lee, {Sang Kook} and Seo, {Eun Kyoung}",

year = "2002",

month = dec,

language = "English",

volume = "8",

pages = "165--169",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "4",

}

TY - JOUR

T1 - Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells

AU - Park, Gowooni

AU - Lee, Eun Jin

AU - Min, Hye Young

AU - Choi, Hye Young

AU - Han, Ah Reum

AU - Lee, Sang Kook

AU - Seo, Eun Kyoung

PY - 2002/12

Y1 - 2002/12

N2 - One-hundred and twenty plant extracts were prepared from 29 cIndonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of ED50<20 μg/ml. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with ED50 values ranging from 0.25 to 0.46 μg/ml. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.

AB - One-hundred and twenty plant extracts were prepared from 29 cIndonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of ED50<20 μg/ml. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with ED50 values ranging from 0.25 to 0.46 μg/ml. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.

KW - Cytotoxicity

KW - Indonesian plants

KW - Plant extracts

KW - Zingiber cassumunar

UR - http://www.scopus.com/inward/record.url?scp=0036967151&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0036967151

SN - 1226-3907

VL - 8

SP - 165

EP - 169

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 4

ER -

Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells

Abstract

Keywords

Fingerprint

Cite this