Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells

Gowooni Park, Eun Jin Lee, Hye Young Min, Hye Young Choi, Ah Reum Han, Sang Kook Lee, Eun Kyoung Seo

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8 Scopus citations

Abstract

One-hundred and twenty plant extracts were prepared from 29 cIndonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of ED50<20 μg/ml. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with ED50 values ranging from 0.25 to 0.46 μg/ml. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalNatural Product Sciences
Volume8
Issue number4
StatePublished - Dec 2002

Keywords

  • Cytotoxicity
  • Indonesian plants
  • Plant extracts
  • Zingiber cassumunar

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