Evaluation of a microreservoir-type biodegradable microcapsule for controlled release of proteins

Hongkee Sah, Yie W. Chien

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21 Scopus citations


For the controlled release of a model protein bovine serum albumin, a biodegradable microreservoir-type microcapsule was prepared. BSA was incorporated into the microcapsules with high efficiency of 96.1 (±3.1)% The encapsulation did not cause any changes in the molecular weight and conformation of BSA, which was proven by biochemical analyses such as gel electrophoresis, circular dichroism, and HPLC. The compositions and fabrication technique of microcapsules were found to be closely related to the release of BSA from the microcapsules and their degradation. Depending on microcapsule formulations, the in vitro release profile of BSA was either monophasic or biphasic. The microcapsules provided various release rates. It was also possible to control the delay before the initiation of BSA release and total duration of its delivery.

Original languageEnglish
Pages (from-to)1243-1263
Number of pages21
JournalDrug Development and Industrial Pharmacy
Issue number11
StatePublished - 1993

Bibliographical note

Funding Information:
The authors wish to express their appreciation for the Johnson and Johnson fellowship awarded to HongKee Sah, and wish to thank the kind assistance of Mr. Rajesh Pate1 in using scanning electron microscope.


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