Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts

Yoo Jin Lee, Eunyoung Lee, Ah Reum Han, Jun Im Song, Youngjoo Kwon, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

Abstract

Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalNatural Product Sciences
Volume18
Issue number2
StatePublished - Jun 2012

Keywords

  • μ-calpain
  • Alveopora japonica
  • Cathepsin b
  • Coral
  • Hexadecyl tetradecanoate
  • Korean indigenous marine organism

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