Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts

Yoo Jin Lee; Eunyoung Lee; Ah Reum Han; Jun Im Song; Youngjoo Kwon; Eun Kyoung Seo

Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts

Yoo Jin Lee, Eunyoung Lee, Ah Reum Han, Jun Im Song, Youngjoo Kwon, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC₅₀ << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC₅₀ values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC_5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Natural Product Sciences
Volume	18
Issue number	2
State	Published - Jun 2012

Keywords

Alveopora japonica
Cathepsin b
Coral
Hexadecyl tetradecanoate
Korean indigenous marine organism
μ-calpain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{3bdde0934d674979ac890057df80d518,

title = "Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts",

abstract = "Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study.",

keywords = "Alveopora japonica, Cathepsin b, Coral, Hexadecyl tetradecanoate, Korean indigenous marine organism, μ-calpain",

author = "Lee, {Yoo Jin} and Eunyoung Lee and Han, {Ah Reum} and Song, {Jun Im} and Youngjoo Kwon and Seo, {Eun Kyoung}",

year = "2012",

month = jun,

language = "English",

volume = "18",

pages = "102--105",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "2",

}

TY - JOUR

T1 - Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts

AU - Lee, Yoo Jin

AU - Lee, Eunyoung

AU - Han, Ah Reum

AU - Song, Jun Im

AU - Kwon, Youngjoo

AU - Seo, Eun Kyoung

PY - 2012/6

Y1 - 2012/6

N2 - Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study.

AB - Marine organism extracts were prepared from 26 species of Korean indigenous marine organisms, including 25 species belonging in class Anthozoa of phylum Cnidaria and a species belonging to subphylum Urochordata of phylum Chordata, and screened their inhibitory effects against μ-calpain. As a result, the thirteen extracts were found to be active in the criteria of IC50 << 100 μg/mL. Among them, the MeOH extracts of Plexauroides praelonga and Alveopora japonica showed remarkable μ-calpain inhibitory activity with IC50 values of 4.62 ± 0.22 and 4.82 ± 0.07 μg/mL, respectively. In addition, chemical investigation of A. japonica led to the isolation of an active compound, hexadecyl tetradecanoate, as a selective cathepsin B inhibitor (IC5o = 9.05 ± 2.45 μM). This compound was isolated as constituent of A. japonica for the first time in the present study.

KW - Alveopora japonica

KW - Cathepsin b

KW - Coral

KW - Hexadecyl tetradecanoate

KW - Korean indigenous marine organism

KW - μ-calpain

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M3 - Article

AN - SCOPUS:84865216680

SN - 1226-3907

VL - 18

SP - 102

EP - 105

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 2

ER -

Evaluation of μ-calpain inhibitory activity of Korean indigenous marine organism extracts

Abstract

Keywords

UN SDGs

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