TY - JOUR
T1 - Estimated glomerular filtration rates show minor but significant differences between the single and subgroup creatinine-based chronic kidney disease epidemiology collaboration equations
AU - Park, Sholhui
AU - Jeong, Tae Dong
N1 - Publisher Copyright:
© Korean Society for Laboratory Medicine.
PY - 2019
Y1 - 2019
N2 - The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation can be calculated according to race, sex, and creatinine concentration (subgroup equation) or in the form expressed by one equation (single equation). Minor differences in the constants used in the CKD-EPI equations (subgroup vs single equations) could result in a significant difference in the estimated glomerular filtration rate (eGFR). We evaluated the impact of this difference in 79, 709 Korean patients. The eGFR was calculated as an integer using the single and subgroup CKD-EPI equations. The differences in eGFR and GFR categories between the equations were analyzed. eGFR was higher in the subgroup equation than the single equation by 1 mL/min/1.73 m 2 for 12, 476 (27.4%) Korean females. The GFR category based on the subgroup equation was reclassified using the single equation for 352 (0.77%) females. Based on the results, the constant of the single equation was optimized. There was no difference in eGFR values between equations using a multiplier of 1.0213 instead of 1.018 for the "white or other" females constant in the single CKD-EPI equation. Clinicians should carefully apply the CKD-EPI equation because eGFR values may differ by 1 mL/min/1.73 m 2 depending on the manner of calculation. To minimize these differences, the constants of the single equation should be revised.
AB - The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation can be calculated according to race, sex, and creatinine concentration (subgroup equation) or in the form expressed by one equation (single equation). Minor differences in the constants used in the CKD-EPI equations (subgroup vs single equations) could result in a significant difference in the estimated glomerular filtration rate (eGFR). We evaluated the impact of this difference in 79, 709 Korean patients. The eGFR was calculated as an integer using the single and subgroup CKD-EPI equations. The differences in eGFR and GFR categories between the equations were analyzed. eGFR was higher in the subgroup equation than the single equation by 1 mL/min/1.73 m 2 for 12, 476 (27.4%) Korean females. The GFR category based on the subgroup equation was reclassified using the single equation for 352 (0.77%) females. Based on the results, the constant of the single equation was optimized. There was no difference in eGFR values between equations using a multiplier of 1.0213 instead of 1.018 for the "white or other" females constant in the single CKD-EPI equation. Clinicians should carefully apply the CKD-EPI equation because eGFR values may differ by 1 mL/min/1.73 m 2 depending on the manner of calculation. To minimize these differences, the constants of the single equation should be revised.
KW - Constant modification
KW - Creatinine-based Chronic Kidney Disease Epidemiology Collaboration equation
KW - Glomerular filtration rate
UR - http://www.scopus.com/inward/record.url?scp=85056645877&partnerID=8YFLogxK
U2 - 10.3343/alm.2019.39.2.205
DO - 10.3343/alm.2019.39.2.205
M3 - Article
C2 - 30430784
AN - SCOPUS:85056645877
VL - 39
SP - 205
EP - 208
JO - Annals of Laboratory Medicine
JF - Annals of Laboratory Medicine
SN - 2234-3806
IS - 2
ER -