Epstein-Barr Virus and Gastrointestinal Lymphomas in Korea

Woo Ick Yang, Min Sun Cho, Yasuhiko Tomita, Masahiko Ohsawa, Katsuyuki Aozasa

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


To analyze the association of Epstein-Barr virus (EBV) with gastrointestinal non-Hodgkin's lymphomas arising in immunocompetent patients, 56 consecutive cases of gastrointestinal lymphomas (B-cell: 52 cases, T-cell 3 cases, T/NK-cell 1 case) occurring in the stomach (33 cases), intestine (22 cases) and esophagus (1 case) were investigated for the presence of EBV using polymerase chain reaction analysis as a screening method followed by EBER-1 RNA and DNA in situ hybridization (ISH) and immunohistochemistry for the expression of latent membrane protein 1 (LMP-1). Forty-seven cases demonstrated extractable DNA and EBV DNA was detected only in 4 cases. Among them, RNA (EBER-1) and DNA ISH analysis confirmed the presence of the EBV genome in tumor cells in 3 cases (T/NK-cell lymphoma of ileum, gastric high-grade B-cell lymphoma of mucosa-associated lymphoid tissue, gastric diffuse large B-cell lymphoma). Only the T/NK cell lymphoma showed diffuse positivity of tumor cells while 2 gastric B-cell lymphomas demonstrated a scattered positive reaction and no cases expressed LMP-1. Nine cases without extractable DNA by the PCR method showed no nuclear signal by EBER-1 ISH. These findings suggest that most sporadic primary gastrointestinal lymphomas in Korea are not associated with EBV.

Original languageEnglish
Pages (from-to)268-276
Number of pages9
JournalYonsei Medical Journal
Issue number3
StatePublished - 1998


  • Epstein-Barr virus
  • Gastrointestinal lymphomas
  • In situ hybridization
  • Polymerase chain reaction


Dive into the research topics of 'Epstein-Barr Virus and Gastrointestinal Lymphomas in Korea'. Together they form a unique fingerprint.

Cite this