Epigenetic regulation in cell reprogramming revealed by genome-wide analysis

Chang Pyo Hong, Jihwan Park, Tae Young Roh

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Cell reprogramming has been known to accompany cell type-specific epigenetic alterations of the genome. Chromatin structure and dynamics influenced by epigenetic factors such as covalent histone modifications, histone variants, DNA methylation, ncRNAs and chromatin remodeling play an important role in determining cell fate. The rapid progress made with the development of high-throughput technology and the systematic assessment of accumulated data has enabled the identification of previously unknown biological processes and disease states in terms of whole-genome profiles of epigenetic signatures at a high resolution. In this article, we discuss the fundamental advances and challenges over the past several years in our knowledge of chromatin state and gene transcription programs associated with epigenetic changes during cell reprogramming processes. In particular, histone modifications, DNA methylation and transcriptome analyses in genome-scale studies will be reviewed to characterize a functional cross-talk between epigenetic and transcriptional regulations in cell reprogramming.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
Issue number1
StatePublished - Feb 2011


  • DNA methylation
  • cell reprogramming
  • embryonic stem cell
  • epigenetic regulation
  • epigenome sequencing
  • histone modification
  • induced pluripotent stem cell
  • small RNA


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