(-)-Epigallocatechin-3-gallate enhances uncoupling protein 2 gene expression in 3T3-L1 adipocytes

Mak Soon Lee, Yangha Kim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

In this study, we investigated the effects of green tea (-)-epigallocatechin-3-gallate (EGCG) on the mRNA level and promoter activity of uncoupling protein 2 (UCP2), a mitochondrial membrane transporter that regulates energy expenditure and thermogenesis in 3T3-L1 adipocytes. EGCG up-regulated the UCP2 mRNA level in a dose-dependent manner. UCP2 promoter activity was significantly stimulated by EGCG treatment, to an extent similar to that seen in mRNA expression. These results suggest that expression of UCP2 gene is directly regulated by green tea EGCG, which is mediated through the transcriptional activation of its proximal promoter.

Original languageEnglish
Pages (from-to)434-436
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number2
DOIs
StatePublished - 2009

Keywords

  • (-)-epigallocatechin-3-gallate (EGCG)
  • 3T3-L1 adipocytes
  • MRNA
  • Promoter activity
  • Uncoupling protein 2 (UCP2)

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