Epidemiology of adult chronic cough: Disease burden, regional issues, and recent findings

Ji Hyang Lee, Sung Yoon Kang, Youngsang Yoo, Jin An, So Young Park, Ji Ho Lee, Seung Eun Lee, Min Hye Kim, Yoshihiro Kanemitsu, Yoon Seok Chang, Woo Jung Song

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Chronic cough is a common medical condition that has a significant impact on patients' quality of life. Although it was previously considered a symptom of other disorders, it is now regarded as a pathologic state that is characterized by a deviation from the intrinsic protective functions of the cough reflex, especially in adults. There are several factors that may underlie the cough reflex hypersensitivity and its persistence, such as age, sex, comorbidities, viral infection, exposure to irritants or environmental pollutants, and their interactions may determine the epidemiology of chronic cough in different countries. With a deeper understanding of disease pathophysiology and advanced research methodology, there are more attempts to investigate cough epidemiology using a large cohort of healthcare population data. This is a narrative overview of recent findings on the disease burden, risk factors, Asia-Pacific issues, and longitudinal outcomes in adults with chronic cough. This paper also discusses the approaches utilizing routinely collected data in cough research.

Original languageEnglish
Article numbere38
JournalAsia Pacific Allergy
Issue number4
StatePublished - Oct 2021

Bibliographical note

Publisher Copyright:
© 2021. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


  • Asia-Pacific
  • Burden of disease
  • Cough
  • Epidemiology
  • Longitudinal outcome
  • Risk factor


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