TY - JOUR
T1 - Epicardial fat thickness is associated to type 2 diabetes mellitus in Korean men
T2 - A cross-sectional study
AU - Chun, Hyejin
AU - Suh, Eunkyung
AU - Byun, A. Eunkyung
AU - Park, Hae Ran
AU - Shim, Kyung Won
N1 - Publisher Copyright:
© 2015 Chun et al.; licensee BioMed Central.
PY - 2015/5/3
Y1 - 2015/5/3
N2 - Background: Visceral fat, including epicardial fat (EF) is recognized as a responsible factor of cardiovascular disease. The aim of this study was to investigate the relationship between EF and diabetes in Korean men. Methods: EF thickness was measured in the left main coronary artery fat tissue (LMCA-fat) by low-dose chest CT scans in 1,048 Korean men (age above 20 years). LMCA-fat values were divided into quartiles and the prevalence of diabetes was analyzed based on the quartiles of LMCA-fat values using logistic regression. Results: There were significant correlations between LMCA-fat and body mass index (r = 0.169, p = 0.004), waist circumference (r = 0.172, p < 0.001), fasting glucose (r = 0.106, p = 0.037) and HbA1c (r = 0.176, p < 0.001). The patients in the higher LMCA-fat quartiles were associated with higher prevalence of diabetes (p for trend <0.001). Even after adjustment for multiple covariates, this association still remained statistically significant (p for trend = 0.022). The highest LMCA-fat quartile group was significantly associated with diabetes compared to the lowest quartile group. (OR = 3.26, 95% CI = 1.17-9.12). Conclusion: These findings indicate that increased EF thickness is independently associated with the prevalence of diabetes in Korean men.
AB - Background: Visceral fat, including epicardial fat (EF) is recognized as a responsible factor of cardiovascular disease. The aim of this study was to investigate the relationship between EF and diabetes in Korean men. Methods: EF thickness was measured in the left main coronary artery fat tissue (LMCA-fat) by low-dose chest CT scans in 1,048 Korean men (age above 20 years). LMCA-fat values were divided into quartiles and the prevalence of diabetes was analyzed based on the quartiles of LMCA-fat values using logistic regression. Results: There were significant correlations between LMCA-fat and body mass index (r = 0.169, p = 0.004), waist circumference (r = 0.172, p < 0.001), fasting glucose (r = 0.106, p = 0.037) and HbA1c (r = 0.176, p < 0.001). The patients in the higher LMCA-fat quartiles were associated with higher prevalence of diabetes (p for trend <0.001). Even after adjustment for multiple covariates, this association still remained statistically significant (p for trend = 0.022). The highest LMCA-fat quartile group was significantly associated with diabetes compared to the lowest quartile group. (OR = 3.26, 95% CI = 1.17-9.12). Conclusion: These findings indicate that increased EF thickness is independently associated with the prevalence of diabetes in Korean men.
KW - Diabetes
KW - Epicardial fat tissue
KW - Low-dose chest CT
KW - Visceral fat
UR - http://www.scopus.com/inward/record.url?scp=84930198540&partnerID=8YFLogxK
U2 - 10.1186/s12933-015-0210-7
DO - 10.1186/s12933-015-0210-7
M3 - Article
C2 - 25935836
AN - SCOPUS:84930198540
SN - 1475-2840
VL - 14
JO - Cardiovascular Diabetology
JF - Cardiovascular Diabetology
IS - 1
M1 - 46
ER -